Comparison of the nucleotide substitution rate of the hepatitis C virus in mothers and their infants

• Project/Area Number: 20790737
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Nagoya City University
• Principal Investigator: ITO Koichi Nagoya City University, 大学院・医学研究科, 助教 (00444977)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: HCV遺伝子 / NS5B母子感染 / HCV / 遺伝子 / BS5B / 母子感染 / NS5B

Research Abstract

The phylogenetic analysis of the NS5b region of the HCV genome was useful for proving mother-to-infant transmission of HCV. The evolution of NS5b did not increase in infants infected through mother-to-infant transmission in childhood. The lower immunological pressure generated by the infant host may affect viral evolution.

Research Products

• [Presentation] 副作用のためPEG-IFN投与を中止し, 陰性化していたHCV-RNAが陽転したが, 自然経過で再び陰性化した男児例 (2008)
  • Author(s): 遠藤剛、伊藤孝一、後藤健之、杉浦時雄、今峰浩貴、安藤直樹、植田昭仁、水野晴夫、杉山幸八郎、戸苅創
  • Organizer: 第35回日本小児栄養消化器肝臓学会
  • Place of Presentation: 東京
• [Presentation] Comparison of the nucleotide substitution rate of the hepatitis C virus NS5b region in mothers and their infants. World Congress of Pediatric Gastroenterology (2008)
  • Author(s): Kenji Goto, Koichi Ito, Tokio Sugiura, Anis Khan, Yasuhito Tanaka, Masashi Mizokami
  • Organizer: Hepatology and Nutrition.
  • Place of Presentation: Iguassu, Brazil
• [Presentation] Polymorphisms of the Factor VII Gene Associated with the Low Activities of Vitamin K-Dependent Coagulation Factors in One-Month-Old Infants. (2008)
  • Author(s): Koichi Ito, Kenji Goto, Tokio Sugiura, Kanji Muramatsu, Toshihiro Ando, Hiroko Maniwa, Takao Yokoyama, Kohachiro Sugiyama, Hajime Togari
  • Organizer: World Congress of Pediatric Gastroenterology, Hepatology and Nutrition.
  • Place of Presentation: Iguassu, Brazil
• [Presentation] 高ガラクトース血症を合併したNICCD患児に対するMCTミルクの有用性 (2008)
  • Author(s): 伊藤孝一、遠藤剛、今峰浩貴、安藤直樹、後藤健之、伊藤哲哉、戸苅創、杉浦時雄、河地豊、小林圭子
  • Organizer: 第25回日本小児肝臓研究会
  • Place of Presentation: 東京