• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Angiotensin II in coronary artery lesion of Kawasaki disease

Research Project

Project/Area Number 20790750
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTokai University

Principal Investigator

SUGANUMA Eisuke  Tokai University, 医学部, 助教 (60408010)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords小児循環器 / 川崎病 / アンギオテシン受容体拮抗薬 / 川崎病モデルマウス / マクロファージ / アンギオテンシン受容体拮抗薬 / アンギオテンシン / カテプシン
Research Abstract

Extracellular matrix(ECD) such as INF-γ,TNF-α,IL-6,MMPs are thought to be involved in coronary artery lesions (CAL) in patients with Kawasaki disease (KD). The mechanisms underlying effects of ARB in CAL are not known. We discussed whether ARB could prevent Lactobacillus casei cell wall extract (LCWE)-induced coronary arteritis in murine model of KD. Inflammations in response to LCWE, are suppressed by ARB treatment. More interestingly, MMP-2, MMP-9, IL-6 mRNA expression at local coronary artery significantly decreased in mice treated with ARB compared with mice post-LCWE injection. Thus, this result suggests that ARB is expected to be a new therapeutic agent for preventing CAL in patient with Kawasaki disease.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (2 results)

All 2011 Other

All Presentation (1 results) Remarks (1 results)

  • [Presentation] アンギオテンシン受容体拮抗薬(ARB)は川崎病モデルマウスにおいてIL-6、MMP-2、MMP-9mRNA発現量を抑制した2011

    • Author(s)
      菅沼栄介、松田晋一、中村英明、関根佳織、新村文男、望月博之
    • Organizer
      第47回日本小児循環器学会学術集会
    • Year and Date
      2011-07-07
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi