Development of novel melanoma marker using tumor specific DNA methylation

• Project/Area Number: 20790787
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: University of Tsukuba
• Principal Investigator: FURUTA Junichi University of Tsukuba, 大学院・人間総合科学研究科, 講師 (30436274)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 癌 / エピジェネティクス / 悪性黒色腫 / DNAメチル化 / 腫瘍マーカー

Research Abstract

We aimed to find the seeds for melanoma molecular marker using melanoma specific DNA methylation. The methylation of RASSF1A was detected in 20% of melanocyitic nevus specimens, whereas in 36% of malignant melanoma specimens. These result suggest that ras signaling pathway including RASSF1 plays an important role in melanocyitic tumors regardless malignant or benign.

Research Products

• [Journal Article] Tumor lysis syndrome after transcatheter arterial infusion of cisplatin and embolization therapy for liver metastases of melanoma (2009)
  • Author(s): Yoshiyuki Nakamura, Yasuhiro Nakamura, Enmi Hori, Junichi Furuta, Yoshiyuki Ishii, Takenori Takahashi, Yasuhiro Kawachi, Fujio Otsuka
  • Journal Title: International Journal of Dermatology 48(7) Pages: 763-7
  • Peer Reviewed
• [Journal Article] Tumor lysis syndrome after transcatheter arterial, infusion of cisplatin and embolization therapy for liver metastases of melanoma (2009)
  • Author(s): Y Nakamura, J Furuta, et al.
  • Journal Title: International Journal of Dermatology 48 Pages: 763-7
  • Peer Reviewed
• [Presentation] Promoter methylation profiling of 28 genes in human cutaneous squamous cell carcinoma (2009)
  • Author(s): Masayuki Sakiyama, Junichi Furuta, Yasuhiro Fujisawa, Yasuhiro Nakamura, Yoshiyuki Ishii, Yasuhiro Kawachi, Shingo Tajima, Fujio Otsuka
  • Organizer: 39th Annual European Society for Dermatological Research Meeting
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2009-09-12
• [Presentation] 皮膚扁平上皮がんの28遺伝子プロモーター領域メチル化プロファイリング (2009)
  • Author(s): 古田淳一
  • Organizer: 欧州研究皮膚科学会
  • Place of Presentation: ブダペスト(ハンガリー)
  • Year and Date: 2009-09-12
• [Presentation] 皮膚扁平上皮がんにおけるDNAメチル化プロファイリング (2009)
  • Author(s): 崎山真幸, 古田淳一, 多島新吾, 大塚藤男
  • Organizer: 第25回日本皮膚悪性腫瘍学会
  • Place of Presentation: 岡山
  • Year and Date: 2009-05-22