Development of novel melanoma marker using tumor specific DNA methylation
| Project/Area Number |
20790787
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
FURUTA Junichi University of Tsukuba, 大学院・人間総合科学研究科, 講師 (30436274)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 癌 / エピジェネティクス / 悪性黒色腫 / DNAメチル化 / 腫瘍マーカー |
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| Research Abstract |
We aimed to find the seeds for melanoma molecular marker using melanoma specific DNA methylation. The methylation of RASSF1A was detected in 20% of melanocyitic nevus specimens, whereas in 36% of malignant melanoma specimens. These result suggest that ras signaling pathway including RASSF1 plays an important role in melanocyitic tumors regardless malignant or benign.
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Report
(3 results)
Research Products
(5 results)
