The investigation for a new role of cutaneous dendritic cells in an immune regulation

• Project/Area Number: 20790801
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: FUKUNAGA Atsushi Kobe University, 大学院・医学研究科, 助教 (10467649)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 皮膚樹状細胞 / 表皮ランゲルハンス細胞 / 真皮樹状細胞 / 接触過敏反応 / 紫外線免疫抑制 / チオレドキシン

Research Abstract

The immune suppressive effect of UVB, which is a risk factor of skin cancer onset and is used as a remedy of skin inflammatory diseases, was studied. UVB-induced immune suppression was induced by the migration of epidermal Langerhans cells into lymph nodes. In addition, dermal dendritic cells located in the dermis were essential to induce the contact hypersensitivity response corresponding human contact dermatitis.

Research Products

• [Journal Article] Thioredoxin Suppresses the Contact Hypersensitivity Response by Inhibiting Leukocyte Recruitment during the Elicitation Phase. (2009)
  • Author(s): Fukunaga A, Horikawa T, Ogura K, Taguchi K, Xijun Y, Funasaka Y, Takeda M, Nakamura H, Yodoi J, Nishigori C
  • Journal Title: Antioxid Redox Signal 6 Pages: 1227-1235
  • Peer Reviewed
• [Journal Article] Agents that reverse UV-induced immune suppression affectDNA repair. (2009)
  • Author(s): 福永淳(equally contribute)
  • Journal Title: J Invest Dermatol 180(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Thioredoxin Suppresses the Contact Hypersensitivity Response by Inhibiting Leukocyte Recruitment during the Elicitation Phase. (2009)
  • Author(s): 福永淳
  • Journal Title: Antioxid Redox Signal 11 Pages: 1227-1235
  • Peer Reviewed
• [Journal Article] Acquired idiopathic generalized anhidrosis : The possible pathogenic role of mast cells. (2009)
  • Author(s): 福永淳
  • Journal Title: Br J Dermatol 160 Pages: 1337-1340
  • Peer Reviewed
• [Journal Article] Thioredoxin Suppresses the Contact Hypersensitivity Response by Inhibiting Leukocyte Recruitment during the Elicitation Phase (2009)
  • Author(s): 幅永淳
  • Journal Title: Antioxid Redox Signal (in press)
  • Peer Reviewed
• [Journal Article] Dermal dendritic cells, and not langerhans cells, play an essential role in inducing an immune response. (2008)
  • Author(s): Fukunaga A, Khaskhely NM, Sreevidya CS, Byrne SN, Ullrich SE
  • Journal Title: J Immunol 180 Pages: 3057-3064
  • Peer Reviewed
• [Journal Article] Dermal dendritic cells, and not langerhans cells, play an essential role in inducinu an immune response (2008)
  • Author(s): 福永淳
  • Journal Title: J Immunol 180 Pages: 3057-3064
  • Peer Reviewed
• [Presentation] Thioredoxin Suppresses the Contact Hypersensitivity Response by Inhibiting Leukocyte Recruitment during the Elicitation Phase (2009)
  • Author(s): 福永淳
  • Organizer: The Japanese Society for Investigative Dermatology 2009
  • Place of Presentation: JALリゾートシーホークホテル福岡(福岡県)
  • Year and Date: 2009-12-04
• [Presentation] 接触過敏反応を制御する2つの皮膚樹状細胞サブセット (2009)
  • Author(s): 福永淳
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-11-06
• [Presentation] アトピー性皮膚炎と紫外線療法 (2009)
  • Author(s): 福永淳
  • Organizer: 第108回日本皮膚科学会総会・学術大会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2009-04-24
• [Presentation] 接触皮膚炎を制御する2つの皮膚樹状細胞サブセット (2009)
  • Author(s): 福永淳
  • Organizer: 第39回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 産業医科大学
• [Presentation] Chikako Nishigori Thioredoxin Suppresses the Contact Hypersensitivity Response by Inhibiting Leukocyte Recruitment during the Elicitation Phase. (2009)
  • Author(s): Atsushi Fukunaga, Tatsuya Horikawa, Kanako Ogura, Kumiko Taguchi, Xijun Yu, Yoko Funasaka, Masafumi Takeda, Hajime Nakamura, Junji Yodoi
  • Organizer: 日本研究皮膚科学会第34回年次学術大会・総会
  • Place of Presentation: JALリゾートシーホークホテル福岡
• [Presentation] DNA damage and repair: Suppresive effect of administration of human recombinant thioredoxin on inflammation and apoptosis of murine skin induced by ultraviolet B irradiation (2009)
  • Author(s): Ono R, Dien S, Masaki T, Fukunaga A, Nishigori C, Yodoi J
  • Organizer: 15th International Congress on Photobiology
  • Place of Presentation: Germany
• [Presentation] アトピー性皮膚炎と紫外線療法 (2009)
  • Author(s): 福永淳
  • Organizer: 第108回日本皮膚科学会総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Langerin expressing skin dendritic cells serve as immunoregulatory cells by activating NKT cells (2008)
  • Author(s): 福永淳
  • Organizer: 2008 Internatioanal Symposium on DCS
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-05
• [Presentation] Langerhans cells serve as immunoregulatory cells by activating NKT cells (2008)
  • Author(s): 福永淳
  • Organizer: Internatioanal Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-14
• [Presentation] Langerhans cells serve as immunoregulatory cells by activating NKT cells. (2008)
  • Author(s): Atsushi Fukunaga, Noor M. Khaskhley, Coimbatore S, Sreevidya, Stephen E. Ullrich
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 国立京都国際会館
• [Presentation] Ullrich Langerin expressing skin dendritic cells serve as immunoregulatory cells by activating NKT cells (2008)
  • Author(s): Atsushi Fukunaga, Noor M. Khaskhley, Coimbatore S. Sreevidya, Stephen E
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: 神戸