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Structure of Sebosomes, secret membrane vesicles of sebocytes

Research Project

Project/Area Number 20790804
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionEhime University

Principal Investigator

NAGAI Ayako  Ehime University, 医学部附属病院, 助教(特定教員) (90420562)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsセボゾーム / 脂腺細胞 / ヒストン / 抗菌 / 分泌膜小胞 / Sebosomes / Sebocytes / 脂線細胞 / 脂質ラフト
Research Abstract

Rat cultured sebocytes synthesized and secreted Sebosomes. It was suggested that Sebosomes contain various subcellular organelles. Recycling endosomes were involved in distribution and localization of the organelles to form the complex membrane system of Sebosomes. Early and late endosomes, lysosomes, lipid granules and lipid rafts were included in the system, in addition to de nove synthesized proteins.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2010 2009 2008 Other

All Presentation (6 results) Book (2 results) Remarks (1 results)

  • [Presentation] StructureofSebosomes,secretmembranevesiclesofsebocytes2010

    • Author(s)
      永井彩子、澄田道博
    • Organizer
      BMB2010第33回日本分子生物学会年会・第83 回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Structure of Sebosomes, secret membrane vesicles of sebocytes2010

    • Author(s)
      永井彩子、澄田道博
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド、神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] StructureandfunctionofSebosomes,secretmembranevesiclesofsebocytes2009

    • Author(s)
      永井彩子、澄田道博
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2009-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] Structure and function of Sebosomes, secret membrane vesicles of sebocytes2009

    • Author(s)
      永井彩子、澄田道博
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂腺細胞の分泌膜小胞、Sebosomesの構造と機能2008

    • Author(s)
      永井彩子、土屋文彦、澄田道博
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2008-12-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 脂腺細胞の分泌膜小胞、Sebosomesの構造と機能2008

    • Author(s)
      永井彩子、土屋文彦、澄田道博
    • Organizer
      BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      兵庫県神戸市ポートアイランド
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Book] 第1編第1章皮脂改善機能-脂腺細胞の培養系と脂質代謝、および、皮脂改善薬の開発指針(細胞死制御工学~美肌・皮膚防護バイオ素材の開発~)(三羽信比古編著)2009

    • Author(s)
      澄田道博、永井彩子
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Book] 第1編第2章セルライト抑制機能-セルライトに対する脂質代謝改善薬の抑制効果、および、その薬効評価技術(細胞死制御工学~美肌・皮膚防護バイオ素材の開発~)(三羽信比古編著)2009

    • Author(s)
      鈴木清香、三村晴子、澄田道博、永井彩子、三羽信比古
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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