Neuroimaging study about the cognitive impairment of vascular depression

• Project/Area Number: 20790841
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: OKADA Go Hiroshima University, 大学院・医歯薬学総合研究科, 特任助教 (10457286)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血管性うつ病 / 認知機能 / 機能的MRI / 言語流暢性課題 / うつ病 / 潜在性脳梗塞 / fMRI / 前頭前野 / 前帯状回 / 機能的結合

Research Abstract

To characterize the functional neuroanatomy of vascular depression, recovered patients with late-onset major depressive disorder were classified as SCI-positive and SCI-negative. Both groups completed verbal fluency task during functional MRI assessment. The verbal fluency performance was significantly lower in the SCI-positive group than in the SCI-negative group. In functional connectivity analysis, SCI-positive group had a significantly reduced functional connectivity between the anterior cingulate cortex and left frontal cortex during a verbal fluency task.

Research Products

• [Journal Article] Attenuated prefrontal activation during a verbal fluency task in remitted major depression (2009)
  • Author(s): Go Okada, Yasumasa Okamoto, Hidehisa Yamashita, Kazutaka Ueda, Hiroshi Takami, Shigeto Yamawaki
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 423-425
  • Peer Reviewed
• [Journal Article] Attenuated prefrontal activation during a verbal fluency task in remittedmajor depression (2009)
  • Author(s): Go Okada
  • Journal Title: Psychiatry and Clinical Neurosciences 63 Pages: 423-425
  • Peer Reviewed
• [Journal Article] Attenuated prefrontal activation during a verbal fluency task in remitted major depression (2009)
  • Author(s): Go Okada
  • Journal Title: Psychiatry and Clinical Neurosciences 63-3(印刷中)
  • Peer Reviewed
• [Presentation] Toward a functional neuroanatomy of vascular depression: A functional magnetic resonance imaging study (2009)
  • Author(s): Go Okada, Yasumasa Okamoto, Hiroshi Takami, Hidehisa Yamashita, Shigeto Yamawaki
  • Organizer: ICGP 9th Annual Scientific Meeting
  • Place of Presentation: アメリカ合衆国(ボルチモア市)
  • Year and Date: 2009-11-04
• [Presentation] Toward a functional neuroanatomy of vascular depression : A functional magnetic resonance imaging study (2009)
  • Author(s): Go Okada
  • Organizer: ICGP 9th Annual Scientific Meeting
  • Place of Presentation: アメリカ合衆国(ボルチモア市)
  • Year and Date: 2009-11-04
• [Presentation] Brain activation during a verbal fluency task in recovered depressive patients with silent cerebral infarction (2009)
  • Author(s): Go Okada, Yasumasa Okamoto, Hiroshi Takami, Hidehisa Yamashita, Shigeto Yamawaki
  • Organizer: The 39th annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ合衆国(シカゴ市)
  • Year and Date: 2009-10-20
• [Presentation] Attenuated left prefrontal activation during a verbal fluency task in remitted major depression (2008)
  • Author(s): Go Okada, Yasumasa Okamoto, Hidehisa Yamashita, Kazutaka Ueda, Shigeru Morinobu, Shigeto Yamawaki
  • Organizer: The 38th annual meeting of the Society for Neuroscience
  • Place of Presentation: アメリカ合衆国(ワシントンDC)
  • Year and Date: 2008-11-19
• [Presentation] Attenuated left prefrontal activation during a verbal fluency task in remitted major depression (2008)
  • Author(s): Go Okada
  • Organizer: The 38th annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19