Role of splicing factors in the pathogenesis of mood disorders

• Project/Area Number: 20790844
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: UCHIDA Shusaku Yamaguchi University, 大学院・医学系研究科, 助教 (10403669)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 気分障害 / 選択的スプライシング / 遺伝子発現 / 撰択的スプライシング

Research Abstract

In this study, we examined the expression analyses of genes which are involved in the regulation of splicing and transcription in mood disorder patients. We found that the expression of SRp20, nPTB, and HDACs mRNAs were altered in patients with mood disorders. Thus our results suggest the aberrant regulations of alternative splicing and transcription in mood disorder.

Research Products

• [Journal Article] Altered gene expression of histone deacetylases in mood disorder patients. (2010)
  • Author(s): Hobara T, Uchida S, Otsuki K, Matsubara T, Funato H, Matsuo K, Suetsugi M, Watanabe Y.
  • Journal Title: Journal of Psychiatric Research 44 Pages: 378-384
  • Peer Reviewed
• [Journal Article] Maternal and genetic factors in stress-resilient and -vulnerable rats: A cross-fostering study. (2010)
  • Author(s): Uchida S, Hara K, Kobayashi A, Otsuki K, Hobara T, Yamagata H, Watanabe Y.
  • Journal Title: Brain Research 1316 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Aberrant REST-mediated transcriptional regulation in major depressive disorder (2010)
  • Author(s): Otsuki K, Uchida S, Wakabayashi Y, Matsubara T, Hobara T, Funato H, Watanabe Y.
  • Journal Title: Journal of Psychiatric Research 44 Pages: 263-270
  • Peer Reviewed
• [Journal Article] Altered gene expression of histone deacetylases in mood disorder patients (2010)
  • Author(s): Teruyuki Hobara, et al.
  • Journal Title: Journal of Psychiatric Research 44 Pages: 263-270
  • Peer Reviewed
• [Journal Article] Aberrant REST-mediated transcriptional regulation in major depressive disorder. (2010)
  • Author(s): Koji Otsuki, et al.
  • Journal Title: Journal of Psychiatric Research 44 Pages: 378-384
  • Peer Reviewed
• [Journal Article] Maternal and genetic factors in stress-resilient and-vulnerable rats : A cross-fostering study. (2010)
  • Author(s): Shusaku Uchida, et al.
  • Journal Title: Brain Research 1316 Pages: 43-50
  • Peer Reviewed
• [Journal Article] Characterization of the vulnerability to repeated restraint stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. (2008)
  • Author(s): Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y.
  • Journal Title: European Journal of Neuroscience 27 Pages: 2250-2261
  • Peer Reviewed
• [Journal Article] Altered expression of neurotrophic factors in patients with major depression. (2008)
  • Author(s): Otsuki K, Uchida S, Watanuki T, Wakabayashi Y, Fujimoto M, Matsubara T, Funato H, Watanabe Y.
  • Journal Title: Journal of Psychiatric Research 42 Pages: 1145-1153
  • Peer Reviewed
• [Journal Article] Reduced expression of glyoxalase-1 mRNA in mood disorder patients. (2008)
  • Author(s): Fujimoto M, Uchida S, Watanuki T, Wakabayashi Y, Otsuki K, Matsubara T, Suetsugi M, Funato H, Watanabe Y.
  • Journal Title: Neuroscience Letters 438 Pages: 196-199
  • Peer Reviewed
• [Journal Article] State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. (2008)
  • Author(s): Wakabayashi Y, Uchida S, Funato H, Matsubara T, Watanuki T, Otsuki K, Fujimoto M, Nishida A., Watanabe Y.
  • Journal Title: Prog. Neuropsychopharmacol. Biol. Psychiatry 32 Pages: 1199-1205
  • Peer Reviewed
• [Journal Article] Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients. (2008)
  • Author(s): Watanuki T, Funato H, Uchida S, Matsubara T, Kobayashi A, Wakabayashi Y, Otsuki K, Nishida A, Watanabe Y
  • Journal Title: Journal of Affective Disorders 110 Pages: 62-69
  • Peer Reviewed
• [Journal Article] Increased expression of splicing factor SRp20 mRNA in bipolar disorder patients (2008)
  • Author(s): Toshio Watanuki, 他
  • Journal Title: Journal of Affective Disorders 110 Pages: 62-69
  • Peer Reviewed
• [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the ventral striatum modulates behavioral vulnerability to stress. (2009)
  • Author(s): Shusaku Uchida, et al.
  • Organizer: Society for Neuroscience
  • Place of Presentation: シカゴ
  • Year and Date: 2009-10-19
• [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the ventral striatum modulates behavioral vulnerability to stress (2009)
  • Author(s): Shusaku Uchida
  • Organizer: Society for Neuroscience
  • Place of Presentation: 米国シカゴ
  • Year and Date: 2009-10-19
• [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress. (2009)
  • Author(s): Shusaku Uchida, et al.
  • Organizer: 第32回日本神経科学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] HDAC2-mediated epigenetic repression of the GDNF gene in the striatum modulates behavioral vulnerability to stress (2009)
  • Author(s): Shusaku Uchida
  • Organizer: 第32回日本神経科学会年会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] Epigenetic regulation of GDNF gene in a mouse model of depression and antidepressant action. (2009)
  • Author(s): Shusaku Uchida, et al.
  • Organizer: 第31回日本生物学的精神医学会年会
  • Place of Presentation: 京都
  • Year and Date: 2009-04-24