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Effect of repetitive transcranial magnetic stimulation and regionalcerebral brood flow in schizophrenia

Research Project

Project/Area Number 20790855
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

OKUMURA Masatoshi  Wakayama Medical University, 医学部, 助教 (00464678)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords精神生理学 / 統合失調症 / 経頭蓋磁気刺激 / 幻聴 / very late onset schizophrenia like psychosis / SPECT / 認知機能
Research Abstract

A 62-year-old woman with resistant auditory hallucinations after low frequency rTMS, who was fulfilled at criteria of very late onset schizophrenia like psychosis was examined using brain single photon emission computed tomography (SPECT) with 99mTc-ECD. We assessed hallucination score, PANSS and Brief Assessment of Cognition in Schizophrenia. Changes in regional cerebral blood flow (rCBF) after rTMS treatment were assessed using a three-dimensional stereotaxic ROI template (3DSRT). Following rTMS, rCBF was decreased in the temporoparietal cortex and increased in the subcortical structures. rTMS did not result in a therapeutic effect. Verbal memory and token motor improved after rTMS. From our findings, we propose that rCBF values in temporoparietal cortex are similar to those reported in previous reports, while those in cortical regions suggest background brain dysfunctions in very late onset schizophrenia like psychosis with auditory hallucinations.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (13 results) Book (1 results)

  • [Journal Article] Evaluation of regional cerebral blood flow in a patient with musical hallucinations2010

    • Author(s)
      Shoyama m, Ukai S, Kitabata Y, Yamamoto M, Okumura M, Kose A, Tsuji T, Shinosaki K.
    • Journal Title

      Neurocase 16

      Pages: 1-6

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of regional cerebral blood flow in a patient with musical hallucinations.2010

    • Author(s)
      Shoyama m, et al
    • Journal Title

      Neurocase 16

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 篠崎和弘統合失調症におけるプレパルス抑制(PPI)の障害2009

    • Author(s)
      鵜飼聡、奥村匡敏、辻富基美
    • Journal Title

      臨床脳波 51巻

      Pages: 441-448

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 和歌山県下で最初の修正型電気けいれん療法実施について2009

    • Author(s)
      小瀬朝海、山本眞弘、正山勝、奥村匡敏、上山栄子、辻富基美、木本吉紀、鵜飼聡、篠崎和弘
    • Journal Title

      和歌山医学 60巻

      Pages: 61-64

    • Related Report
      2009 Final Research Report
  • [Journal Article] 統合失調症におけるプレパルス抑制(PPI)の障害2009

    • Author(s)
      鵜飼聡, 他
    • Journal Title

      臨床脳波 51

      Pages: 441-448

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 和歌山県下で最初の修正型電気けいれん療法実施について2009

    • Author(s)
      小瀬朝海, 他
    • Journal Title

      和歌山医学 60

      Pages: 61-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 篠崎和弘統合失調症のminor physical anomalies (MPAs)と家族歴の検討2008

    • Author(s)
      奥村匡敏、岩谷潤, 山本眞弘, 正山勝, 上山栄子, 小瀬朝海, 辻富基美, 鵜飼聡
    • Journal Title

      精神医学 50巻

      Pages: 873-876

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症のminor physical anomalies(MPAs)と家族歴の検討2008

    • Author(s)
      奥村匡敏, 他
    • Journal Title

      精神医学 50

      Pages: 873-876

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 統合失調症におけるプレパルス抑制と脳血流変化の検討2010

    • Author(s)
      山田信一、奥村匡敏、正山勝、辻富基美、鵜飼聡、篠崎和弘
    • Organizer
      第5回統合失調症学会
    • Place of Presentation
      福岡市
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Aripiprazole投与中にPisa症候群を呈した統合失調症の1例2010

    • Author(s)
      宇本麻衣子、前田智信、奥村匡敏、辻富基美、鵜飼聡、篠崎和弘
    • Organizer
      第106回近畿精神神経学会
    • Place of Presentation
      奈良市
    • Year and Date
      2010-02-13
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 左前頭前野・高頻度rTMSのNIRSを用いた対側の血流変化とDTIにおける異方性の検討2009

    • Author(s)
      奥村匡敏、岩谷潤、高橋隼、橋本忠浩、坂本裕司、北又照康、前田智信、山田信一、石田卓也、池田督司、山本眞弘、正山勝、上山栄子、小瀬朝海、辻富基美、鵜飼聡、篠崎和弘
    • Organizer
      第105回近畿精神神経学会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 磁気刺激療法が奏効した難治性大うつ病患者の脳血流変化の検討2009

    • Author(s)
      高橋隼、辻富基美、奥村匡敏、山本眞弘、馬島將行、篠崎和弘
    • Organizer
      第105回近畿精神神経学会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 篠崎和弘左前頭前野・高頻度rTMSによる対側の血流変化のNIRSを用いた検討2009

    • Author(s)
      奥村匡敏、岩谷潤、山本眞弘、正山勝、上山栄子、小瀬朝海、辻富基美、鵜飼聡
    • Organizer
      第77回和歌山医学会総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-07-04
    • Related Report
      2009 Final Research Report
  • [Presentation] 近赤外分光法(NIRS)の精神疾患への臨床応用2009

    • Author(s)
      正山勝、山本眞弘、奥村匡敏、小瀬朝海、上山栄子、辻富基美、鵜飼聡、篠崎和弘
    • Organizer
      第77回和歌山医学会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] うつ症状に対し反復経頭蓋磁気刺激を行った2症例について2009

    • Author(s)
      辻富基美、高橋隼、山本眞弘、奥村匡敏、正山勝、小瀬朝海、鵜飼聡、篠崎和弘
    • Organizer
      第77回和歌山医学会総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 左前頭前野・高頻度rTMSによる対側の血流変化のNIRSを用いた検討2009

    • Author(s)
      奥村匡敏, 他
    • Organizer
      第77回和歌山医学会総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Kazuhiro Shinosaki Prepulse inhibition as a biological marker of at risk mental state of schizophrenia.2009

    • Author(s)
      Okumura M, Shun Takahashi, Asami Kose, Tomikimi Tsuji, Satoshi Ukai
    • Organizer
      9th World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Year and Date
      2009-07-01
    • Related Report
      2009 Final Research Report
  • [Presentation] Prepulse inhibition as a biological marker of at risk mental state of schizophrenia.2009

    • Author(s)
      Okumura m, et al
    • Organizer
      9^<th> World Congress of Biological Psychiatry
    • Place of Presentation
      パリ
    • Year and Date
      2009-07-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] アットリスク精神状態と初回エピソード統合失調症のプレパルスインヒビションと認知機能の検討2009

    • Author(s)
      奥村匡敏、高橋隼、小瀬朝海、辻富基美、鵜飼聡、篠崎和弘
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 磁気刺激療法を施行した難治性大うつ病患者の神経生理学的評価2009

    • Author(s)
      高橋隼、辻富基美、小瀬朝海、奥村匡敏、正山勝、山本眞弘、鵜飼聡、篠崎和弘
    • Organizer
      第31回Fmθ研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-02-28
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 統合失調症の前駆期、初回エピソードと慢性期におけるプレパルスインヒビションの検討2009

    • Author(s)
      奥村匡敏、鵜飼聡、篠崎和弘
    • Organizer
      第4回日本統合失調症学会
    • Place of Presentation
      吹田市
    • Year and Date
      2009-01-31
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Book] WFSBP2009第9回世界生物学的精神医学会ハイライト2009

    • Author(s)
      奥村匡敏
    • Publisher
      メディカルトリビューン社
    • Related Report
      2009 Annual Research Report 2009 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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