| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We hypothesize that the genetic basis for schizophrenia is mutational events mediated by the mobile elements causing genome instability under the abnormal methylation. These dynamics of mobile elements is not fully fixed, and might be progressively in terms of imprinting or after event onset. Herein, we have attempted the screening of de novo mutations mediated by LINE-1 and Alu in patients from the schizophrenia trios and the sequential samples from patient and control subject. Consequently, we have identified the de novo mutation mediated by LINE-1 and Alu which were specific to patient. Our results suggested that the dynamics of mobile elements might be one of the risk factors for schizophrenia. Further research using screenings of de novo mutations mediated by mobile elements from various samples is needed to clarify the etiology in schizophrenia.
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