Quantitative and time-course analyses of oxidative stress in irradiated mice/rats.
| Project/Area Number |
20790876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Yamagata University |
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Principal Investigator |
NOMIYA Takuma Yamagata University, 医学部, 助教 (60436201)
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| Research Collaborator |
NEMOTO Kenji 山形大学, 医学部, 教授 (10208291)
KANEKO Takashi 山形大学, 医学部・医学科
GOTO Jun 山形大学, 医学部・医学科
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線治療生物学 / 放射線 / フリーラジカル / 動物実験 / 放射線生物 / マウス実験 |
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| Research Abstract |
Recently, oxidative metabolites have been able to be measured by simple small device. Radiation used in radiotherapy causes free radicals and oxidative metabolites, and irradiation causes dermatitis and sometimes causes skin ulcer in the irradiated site. We analyzed the relationships between the value of oxidative metabolites and skin reactions. As a results, a significant correlation was shown between irradiation dose and skin grade. And a significant correlation was also shown between the value of oxidative metabolites and irradiation dose. It was suggested that the value of oxidative metabolites seems to be useful for estimating degree of skin reaction and time to appear skin reaction after irradiation.
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Report
(4 results)
Research Products
(11 results)
