• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Quantitative and time-course analyses of oxidative stress in irradiated mice/rats.

Research Project

Project/Area Number 20790876
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionYamagata University

Principal Investigator

NOMIYA Takuma  Yamagata University, 医学部, 助教 (60436201)

Research Collaborator NEMOTO Kenji  山形大学, 医学部, 教授 (10208291)
KANEKO Takashi  山形大学, 医学部・医学科
GOTO Jun  山形大学, 医学部・医学科
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords放射線治療生物学 / 放射線 / フリーラジカル / 動物実験 / 放射線生物 / マウス実験
Research Abstract

Recently, oxidative metabolites have been able to be measured by simple small device. Radiation used in radiotherapy causes free radicals and oxidative metabolites, and irradiation causes dermatitis and sometimes causes skin ulcer in the irradiated site. We analyzed the relationships between the value of oxidative metabolites and skin reactions. As a results, a significant correlation was shown between irradiation dose and skin grade. And a significant correlation was also shown between the value of oxidative metabolites and irradiation dose. It was suggested that the value of oxidative metabolites seems to be useful for estimating degree of skin reaction and time to appear skin reaction after irradiation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] 放射線照射後のラットにおける酸化ストレス値の経時変化2011

    • Author(s)
      金子崇、後藤準、野宮琢磨、根本建二
    • Journal Title

      山形大学紀要(自然科学) 第17巻第2号

      Pages: 31-39

    • NAID

      110008151157

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線照射後のラットにおける酸化反応物測定値と皮膚障害の関係2011

    • Author(s)
      金子崇、後藤準、野宮琢磨、根本建二
    • Journal Title

      山形大学紀要(医学) 29(1)

      Pages: 19-28

    • NAID

      110008576605

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線照射後のラットにおける酸化ストレス値の経時変化2011

    • Author(s)
      金子崇、後藤準、野宮琢磨、根本建二
    • Journal Title

      山形大学紀要(自然科学)

      Volume: 17(2) Pages: 31-39

    • NAID

      110008151157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線照射後のラットにおける酸化反応物測定値と皮膚障害の関係2011

    • Author(s)
      金子崇、後藤準、野宮琢磨、根本建二
    • Journal Title

      山形大学紀要(医学)

      Volume: 29(1) Pages: 19-28

    • NAID

      110008576605

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 放射線照射ラットにおける血液酸化ストレス値と急性期反応・晩期皮膚障害の関係2010

    • Author(s)
      野宮琢磨、太田伊吹、村上弥沙子、鈴木志恒、和田仁、根本建二
    • Organizer
      第23回日本放射線腫瘍学会
    • Place of Presentation
      千葉、浦安
    • Year and Date
      2010-11-18
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線照射ラットにおける血液酸化ストレス値と急性期反応・晩期皮膚障害の関係2010

    • Author(s)
      野宮琢磨, 他
    • Organizer
      第23回日本放射線腫瘍学会
    • Place of Presentation
      東京ベイ舞浜ホテル(浦安市)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線照射後のラットにおける酸化ストレス値の経時変化-急性期の反応-2010

    • Author(s)
      野宮琢磨、太田伊吹、小林篤紀、村上弥沙子、鈴木志恒、和田仁、根本建二、金子崇、後藤準
    • Organizer
      第121回北日本地方会
    • Place of Presentation
      山形
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線照射後のラットにおける酸化ストレス値と晩期皮膚障害の関係2010

    • Author(s)
      野宮琢磨、太田伊吹、小林篤紀、村上弥沙子、鈴木志恒、和田仁、根本建二、金子崇、後藤準
    • Organizer
      第121回北日本地方会
    • Place of Presentation
      山形
    • Year and Date
      2010-06-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 放射線照射後のラットにおける酸化ストレス値の経時変化-急性期の反応-2010

    • Author(s)
      野宮琢磨, 他
    • Organizer
      日本医学放射線学会第121回北日本地方会
    • Place of Presentation
      キャッスルホテル(山形市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線照射後のラットにおける酸化ストレス値と晩期皮膚障害の関係2010

    • Author(s)
      野宮琢磨, 他
    • Organizer
      日本医学放射線学会第121回北日本地方会
    • Place of Presentation
      キャッスルホテル(山形市)
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi