Radiosensitization with molecular targeted drugs in pancreatic cancer therapy : analysis by tumor imaging
| Project/Area Number |
20790892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kyoto University |
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Principal Investigator |
ITASAKA Satoshi Kyoto University, 医学研究科, 助教 (90378654)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膵癌 / 放射線 / 分子標的 / イメージング / 低酸素 / 分子標的薬 |
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| Research Abstract |
Purpose of this study is to enhance the effects of irradiation on pancreatic cancer with molecular targeted drugs. We evaluated the treatment effects of radiation with anti-VEGF antibody and the change of HIF-1 activity by imaging. We confirmed that irradiation at the timing of low HIF-1 activity is correlated with enhanced irradiation effects. In contrast, when irradiation was given at the timing of high HIF-1 activity, anti-tumor effects of irradiation was decreased. We also revealed that newly developed hypoxia targeted drug achieves longer survival in orthotopic pancreatic cancer model.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.2008
Author(s)
Zeng, L., Ou G, et al.. Zeng L, Ou G, Itasaka S, Harada H, Xie X, Shibuya K, Kizaka-Kondoh S, Morinibu A, Shinomiya K, Hiraoka M
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Journal Title
Cancer Sci 99(11)
Pages: 2327-2335
NAID
Related Report
Peer Reviewed
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