The utility of glial molecular imaging in epileptic animal brain.
| Project/Area Number |
20790896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
HOSOI Rie Osaka University, 大学院・医学系研究科, 助教 (30291446)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | グリア / 酢酸 / ケトン / リチウムピロカルピン / てんかん / げっ歯類 / 脳 / 代謝 / 幼弱ラット / グリア代謝 / モノカルボン酸 / ^<14>C-酢酸 / ^<14>C-乳酸 / 解糖 / ラット / 幼弱動物 / ケトン体 |
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| Research Abstract |
Glial energy metabolism in rat brain was markedly enhanced during a prolonged seizure induced by lithium-pilocarpine (Li-P) model. Glial metabolism was measured with ^<14>C-acetate. The increase of brain uptake was observed in adult (8 weeks old) rat brain. ^<14>C-acetate uptake in young (3 weeks old) rat brain was not changed during status epilepticus (SE), whereas both local cerebral blood flow and glucose metabolism were increased in young rat brain during SE. The anticonvulsant effects of acetone have been reported in various animal models of epilepsy. We also demonstrated that ketone bodies, methyl ethyl ketone (MEK) and diethyl ketone (DEK), suppressed SE that was induced by Li-P in rat. And MEK and DEK showed broad-spectra anticonvulsant effects in both chemically- and electroshock-induced experimental seizure models.
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Report
(4 results)
Research Products
(30 results)
