| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Glial energy metabolism in rat brain was markedly enhanced during a prolonged seizure induced by lithium-pilocarpine (Li-P) model. Glial metabolism was measured with ^<14>C-acetate. The increase of brain uptake was observed in adult (8 weeks old) rat brain. ^<14>C-acetate uptake in young (3 weeks old) rat brain was not changed during status epilepticus (SE), whereas both local cerebral blood flow and glucose metabolism were increased in young rat brain during SE. The anticonvulsant effects of acetone have been reported in various animal models of epilepsy. We also demonstrated that ketone bodies, methyl ethyl ketone (MEK) and diethyl ketone (DEK), suppressed SE that was induced by Li-P in rat. And MEK and DEK showed broad-spectra anticonvulsant effects in both chemically- and electroshock-induced experimental seizure models.
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