Analysis of Molecular mechanisms and radiosensitizing effect of Gimeracil.
Project/Area Number |
20790902
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Radiation science
|
Research Institution | Sapporo Medical University |
Principal Investigator |
MASANORI Someya Sapporo Medical University, 医学部, 助教 (60404711)
|
Project Period (FY) |
2008 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 放射線治療生物学 / 放射線増感剤 |
Research Abstract |
We analyzed molecular mechanisms of radiosensitizing effect of Gimeracil as a clinically expecting therapeutic drug. By using methods of colony formation assay and radiation-induced foci formation assay, we proved that gimeracil partially inhibits homologous recombination in the DNA double strand break repair mechanism and therefore the radiosensitizing effect can be obtained.
|
Report
(3 results)
Research Products
(8 results)