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Development of lung function diagnosis using hyperpolarized Xenon gas

Research Project

Project/Area Number 20790919
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionResearch institute for Brain and Blood Vesseis Akita

Principal Investigator

NAKAMURA Kazuhiro  Research institute for Brain and Blood Vesseis Akita (10312638)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords医療・福祉 / 肺疾患 / MRI / 超偏極希ガス / 核磁気共鳴 / キセノン
Research Abstract

This research is for lung function diagnostic using hyperpolarized 129Xe MRI. Precise anatomical lung image and images of exchange gas function is main object. Exchange gas function in lung is analyzed by resolved 129Xe gas to lung tissue and blood. Lung image with hyperpolarized 129Xe in animal MRI system was established at first, then trials in human MRI system with specific lung coil suited to 129Xe was prepared. Even a spectrum of hyperpolarized 129Xe from human lung was able to be acquired, it was quite difficult for lung image. Our xenon polarization may not be high enough for image. Another possible reason why we cannot get lung image is large diffusion constant in gas itself. Gradient magnetic field for imaging is reduced the NMR signal in diffusible tracer. Mathematical model simulation and our experiment show a reduction related a magnitude of gradient magnetic field. For solve this problem, we now prepared the new sequence program with frequency modulated RF pulses. It should be helpful for high S/N image as far as our preliminary study. Ethic review committee in our laboratory is already approved the human lung MRI with hyperpolarized 129Xe. The experiment protocol has been established through this research.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2009 2008

All Journal Article (6 results) Presentation (2 results)

  • [Journal Article] 勾配磁場による超偏極キセノン129信号の減衰2009

    • Author(s)
      中村和浩, 他
    • Journal Title

      日本磁気共鳴学会雑誌 29S

      Pages: 360-360

    • Related Report
      2009 Final Research Report
  • [Journal Article] 勾配磁場による超偏極キセノン129信号の減衰2009

    • Author(s)
      中村和浩
    • Journal Title

      日本磁気共鳴医学会雑誌 29S

      Pages: 360-360

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脳梗塞再灌流モデルラットにおける超偏極キセノン129スペクトラム2008

    • Author(s)
      中村和浩, 他
    • Journal Title

      日本磁気共鳴学会雑誌 28S

      Pages: 329-329

    • Related Report
      2009 Final Research Report
  • [Journal Article] 脳腫瘍モデルラットにおける超偏極キセノン129スペクトラム2008

    • Author(s)
      中村和浩, 他
    • Journal Title

      日本磁気共鳴学会雑誌 28S

      Pages: 332-332

    • Related Report
      2009 Final Research Report
  • [Journal Article] 脳梗塞再灌流モデルラットにおける超偏極キセノン129スペクトラム2008

    • Author(s)
      中村 和浩
    • Journal Title

      日本磁気共鳴学会雑誌 28S

      Pages: 329-329

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 脳腫瘍モデルラットにおける超偏極キセノン129スペクトラム2008

    • Author(s)
      中村 和浩
    • Journal Title

      日本磁気共鳴学会雑誌 28S

      Pages: 332-332

    • Related Report
      2008 Annual Research Report
  • [Presentation] 超偏極キセノンを利用した肺機能画像取得の試み2009

    • Author(s)
      中村和浩, 他
    • Organizer
      第43回日本生体医工学会東北支部大会
    • Place of Presentation
      福島大学(福島)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 超偏極キセノンを利用した肺機能画像取得の試み2009

    • Author(s)
      中村和浩
    • Organizer
      第43回日本生体医工学会 東北支部大会
    • Place of Presentation
      福島大学(福島)
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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