| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
This research is for lung function diagnostic using hyperpolarized 129Xe MRI. Precise anatomical lung image and images of exchange gas function is main object. Exchange gas function in lung is analyzed by resolved 129Xe gas to lung tissue and blood. Lung image with hyperpolarized 129Xe in animal MRI system was established at first, then trials in human MRI system with specific lung coil suited to 129Xe was prepared. Even a spectrum of hyperpolarized 129Xe from human lung was able to be acquired, it was quite difficult for lung image. Our xenon polarization may not be high enough for image. Another possible reason why we cannot get lung image is large diffusion constant in gas itself. Gradient magnetic field for imaging is reduced the NMR signal in diffusible tracer. Mathematical model simulation and our experiment show a reduction related a magnitude of gradient magnetic field. For solve this problem, we now prepared the new sequence program with frequency modulated RF pulses. It should be helpful for high S/N image as far as our preliminary study. Ethic review committee in our laboratory is already approved the human lung MRI with hyperpolarized 129Xe. The experiment protocol has been established through this research.
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