Analysis of signaling pathway for proliferation and survival of lymphatic endothelial cell and application for clinical therapy against lymphangioma
| Project/Area Number |
20790942
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
FUJINO Akihiro National Research Institute for Child Health and Development, 生殖・細胞医療研究部, 共同研究員 (50306726)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | リンパ管腫 / PI3K / リンパ管腫モデル動物 / MAPK / PI3K/AKT / D2-40 / Podoplanin / Proxl抗体 / 試験管内スクリーニング / AKT |
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| Research Abstract |
PI3K/AKT signaling pathway is activated in lymphatic endothelial cells in human lymphangioma tissue. Inhibitors for PI3K/AKT were applied to human lymphangioma derived lymphatic endothelial cells (HL-LECs) for apoptosis assay, failing to see any specific reaction in vitro.
Five primary HL-LECs were established and transplanted to immunodeficient NOG mice, resulting in lymphangioma-like cystic tissue formation in all cases.
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Report
(4 results)
Research Products
(14 results)
