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Study of Carboxypeptidase M expression profiles in patients with lung cancer

Research Project

Project/Area Number 20790982
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FUJIWARA Naoyuki  東京医科歯科大学, 大学院・医歯学総合研究科, 医系・助教 (80451912)

Co-Investigator(Kenkyū-buntansha) AKASHI Takumi  東京医科歯科大学, 医学部附属病院, 医系・准教授 (60242202)
Project Period (FY) 2008 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsカルボキシペプチダーゼM / Carboxypeptidase M / CPM / 肺がん / Lung Cancer / 肺胞上皮細胞 / 発がん動物モデル / カルボキシペプチターゼM / EGFR / 肺癌 / 蛋白質 / 病理学
Research Abstract

We investigated the localization of CPM in lung cancer of human and rat. Anti-rat CPM antibody 7F9 was applied to a BHP-induced rat lung cancer model. In immunohistochemistry, CPM was localized in the cell membrane of pulmonary alveolar type II epithelial cells in normal tissue part, and also was in the cell membrane of pulmonary cancer part. In immunohistochemistry for CPM and TTF-1, positive cells were well consistent. Expression level of CPM in western blotting was increased with time. Therefore, CPM was considered one of the cancer-related molecules.

Report

(6 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2009

All Presentation (5 results)

  • [Presentation] Localization of Carboxypeptidase M in BHP-induced rat lung adenocarcinomas2009

    • Author(s)
      Naoyuki Fujiwara
    • Organizer
      13th World Conference on Lung Cancer
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット肺癌モデルを使用したカルボキシペプチダーゼMの局在の検討2009

    • Author(s)
      藤原直之,小島勝雄,荒井裕国,熊谷二朗,畑裕
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Localization ofCarboxypeptidase M in BHP-induced ratlung adenocarcinomas. 13th WorldConference on Lung Cancer2009

    • Author(s)
      Naoyuki Fujiwara, Katsuo Kojima, Hirokuni Arai, Jiro Kumagai, YutakaHata
    • Organizer
      San Francisco
    • Place of Presentation
      California, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Localization of Carboxypeptidase M in BHP-induced rat lung adenocarcinomas.2009

    • Author(s)
      Naoyuki Fujiwara, Katsuo Kojima, Hirokuni Arai, Jiro Kumagai, Yutaka Hata
    • Organizer
      13th World Conference on Lung Cancer
    • Place of Presentation
      San Francisco,California,USA
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] 畑裕ラット肺癌モデルを使用したカルボキシペプチダーゼMの局在の検討2009

    • Author(s)
      藤原直之、小島勝雄、荒井裕国、熊谷二朗
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2010 Self-evaluation Report

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Published: 2008-04-01   Modified: 2016-04-21  

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