Study for utility of normal pressure hypoxic training before extensive pulmonary resection.

• Project/Area Number: 20790984
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Gifu University
• Principal Investigator: MATSUMOTO Shinsuke Gifu University, 大学院・医学系研究科, 非常勤講師 (40397352)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 外科 / 肺切除術 / トレーニング

Research Abstract

We evaluated the influence of respiration/circulation following extensive pulmonary resection in rats. We started manufacture of normal pressure hypoxic training model, however, it is not completed. On the other hand, we evaluated the influence of respiration/circulation after pulmonary resection by granulocyte colony-stimulating factor (G-CSF). G-CSF administration suppressed pulmonary hypertension/right ventricular hypertrophy, thus preventing right heart failure after resection. We will train rats before pulmonary resection, and evaluate a further effect.

Research Products

• [Journal Article] Suppression of right ventricular hypertrophy after extensive pulmonary resection in rats by granulocyte colony-stimulating factor
  • Author(s): Shinsuke Matsumoto, Hisashi Iwata, Koyo Shirahashi, Masanao Saio, Yukio Umeda, Tsutomu Marui, Narihiro Ishida, Masaki Kimura, Takuya Sugimoto, Hideaki Manabe, Hirofumi Takemura
  • Journal Title: Journal of Sugical Research (in press)
  • Peer Reviewed
• [Journal Article] Suppression of right ventricular hypertrophy after extensive pulmonary resection in rats by granulocyte colony-stimulating factor.
  • Author(s): Shinsuke Matsumoto, Hisashi Iwata, Koyo Shirahashi, et.al.
  • Journal Title: Journal of Surgical Research (In press)
  • Peer Reviewed
• [Presentation] Suppression of right ventricular hypertrophy after extensive pulmonary resection in rats by granulocyte colony-stimulating factor (2009)
  • Author(s): Shinsuke Matsumoto, Hisashi Iwata, Koyo Shirahashi, Tsutomu Marui, Yoshimasa Mizuno, Hirofumi Takemura
  • Organizer: CHEST 2009: American College of Chest Physicians Annual Meeting
  • Place of Presentation: San Diego
  • Year and Date: 2009-11-04
• [Presentation] Suppression of right ventricular hypertrophy after extensive pulmonary resection in rats by granulocyte colony-stimulating factor. (2009)
  • Author(s): Shinsuke Matsumoto, et.al.
  • Organizer: CHEST 2009 : American College of Chest Physicians Annual Meeting
  • Place of Presentation: Convention center (San Diego)
  • Year and Date: 2009-11-04