Analysis of function of bone morphogenetic protein signaling in bone remodeling and osteoclast formation

• Project/Area Number: 20791033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Osaka University
• Principal Investigator: OKAMOTO Mina Osaka University, 医学系研究科, 特任研究員 (50457008)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 骨形成因子 / コンディショナルノックアウトマウス / 破骨細胞 / 骨代謝 / カテプシンK / 骨形成因子(BMP)

Research Abstract

Bone morphogenetic protein (BMP) is an important protein in the skeletal metabolism. So far it is known that BMP signaling promote osteoblastic differentiation, but its role in osteoclasts is not clear. So we analyzed the key role of BMP signaling in osteoclast. We found that BMP signaling in bone remodeling plays an important roles in the osteoclast, and we considered it is necessary for bone tissue formation and maintenance.

Research Products

• [Journal Article] Insulation of the Ubiquitous Rxrb Promoter from the Cartilage-specific Adjacent Gene, Col11a2. (2008)
  • Author(s): Murai, J., Ikegami, D., Okamoto, M., Yoshikawa, H., Tsumaki, N.
  • Journal Title: J Biol Chem 283 Pages: 27677-27687
• [Journal Article] Insulation of the Ubiquitous Rxrb Promoter from the Cartilage-specific Adjacent Gene. (2008)
  • Author(s): Murai, J., Ikegami, D., Okamoto M., Yoshikawa, H., and Tsumaki, N.
  • Journal Title: J. Biol. Chem. 283 Pages: 27677-27687
  • Peer Reviewed
• [Presentation] Sox9 is Essential for Survival and Hypertrophy of Mature Chondrocytes 56th Annual Meeting of the Orthopaedic Research Society (2010)
  • Author(s): Ikegami, D; Akiyama, H; Kaneko, K; Okamoto, M; Nakamura, T; Yoshikawa, H; Tsumaki, N
  • Place of Presentation: New Orleans, Louisiana
• [Presentation] Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation. (2008)
  • Author(s): T. Iwai, J. Murai, K. Hiramatsu, D. Ikegami, M. Okamoto, H. Yoshikawa, N. Tsumaki
  • Organizer: 7th International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: Lake Tahoe, California
• [Presentation] Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation. (2008)
  • Author(s): T. Iwai, J. Murai, K. Hiramatsu, D. Ikegami, M. Okamoto, H. Yoshikawa, N. Tsumaki
  • Organizer: 7^<th> International Conference on Bone Morphogenetic Proteins
  • Place of Presentation: Lake Tahoe, CA, USA