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Analysis of function of bone morphogenetic protein signaling in bone remodeling and osteoclast formation

Research Project

Project/Area Number 20791033
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionOsaka University

Principal Investigator

OKAMOTO Mina  Osaka University, 医学系研究科, 特任研究員 (50457008)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨形成因子 / コンディショナルノックアウトマウス / 破骨細胞 / 骨代謝 / カテプシンK / 骨形成因子(BMP)
Research Abstract

Bone morphogenetic protein (BMP) is an important protein in the skeletal metabolism. So far it is known that BMP signaling promote osteoblastic differentiation, but its role in osteoclasts is not clear. So we analyzed the key role of BMP signaling in osteoclast. We found that BMP signaling in bone remodeling plays an important roles in the osteoclast, and we considered it is necessary for bone tissue formation and maintenance.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2008

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Insulation of the Ubiquitous Rxrb Promoter from the Cartilage-specific Adjacent Gene, Col11a2.2008

    • Author(s)
      Murai, J., Ikegami, D., Okamoto, M., Yoshikawa, H., Tsumaki, N.
    • Journal Title

      J Biol Chem 283

      Pages: 27677-27687

    • Related Report
      2009 Final Research Report
  • [Journal Article] Insulation of the Ubiquitous Rxrb Promoter from the Cartilage-specific Adjacent Gene.2008

    • Author(s)
      Murai, J., Ikegami, D., Okamoto M., Yoshikawa, H., and Tsumaki, N.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 27677-27687

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sox9 is Essential for Survival and Hypertrophy of Mature Chondrocytes 56th Annual Meeting of the Orthopaedic Research Society2010

    • Author(s)
      Ikegami, D; Akiyama, H; Kaneko, K; Okamoto, M; Nakamura, T; Yoshikawa, H; Tsumaki, N
    • Place of Presentation
      New Orleans, Louisiana
    • Related Report
      2009 Final Research Report
  • [Presentation] Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation.2008

    • Author(s)
      T. Iwai, J. Murai, K. Hiramatsu, D. Ikegami, M. Okamoto, H. Yoshikawa, N. Tsumaki
    • Organizer
      7th International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Lake Tahoe, California
    • Related Report
      2009 Final Research Report
  • [Presentation] Smad7 inhibits chondrocyte differentiation at multiple steps during endochondral bone formation.2008

    • Author(s)
      T. Iwai, J. Murai, K. Hiramatsu, D. Ikegami, M. Okamoto, H. Yoshikawa, N. Tsumaki
    • Organizer
      7^<th> International Conference on Bone Morphogenetic Proteins
    • Place of Presentation
      Lake Tahoe, CA, USA
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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