Effect of bisphosphonate on osteoblast differentiation of mesenchymal stem cells
| Project/Area Number |
20791042
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
FUJITA Hirofumi Okayama University, 大学院・医歯薬学総合研究科, 助教 (20423288)
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| Research Collaborator |
KUROKAWA Kaduko 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ビスフォスフォネート / 骨粗鬆症 / 骨芽細胞 / 間葉系幹細胞 / 分化 / 石灰化 / 骨シアロタンパク質 |
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| Research Abstract |
Our results indicated that bisphoshonate suppressed osteoblast differentiation and suggested that the anti-bone resorptive effect of bisphoshonate is not involved in RANKL expression of MSCs-derived osteoblast. We also found that GGOH strongly suppressed the bisphoshonate-induced apoptosis in MSCs.
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Report
(3 results)
Research Products
(18 results)
