| Project/Area Number |
20791048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
HASHIMOTO Yusuke Osaka City University, 大学院・医学研究科, 講師 (10382178)
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| Research Collaborator |
OHTA Yoichi 大阪市立大学, 大学院・医学研究科, 前期研究医
UEMURA Takuya 大阪市立大学, 大学院・医学研究科, 大学院生
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 骨形成蛋白(Bone morphogenetic protein ; BMP) / 運動 / カテコラミン / 骨形成蛋白(BMP) / PLA-DX-PEG polymer / PLA-DX-PEG polmer |
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| Research Abstract |
Topical effects of a catecholamine on bone morphogenetic protein (BMP)-induced ectopic bone formation were investigated in both in vivo and in vitro experimental systems. The mass of ossicles ectopically induced by BMP-2 was increased by the addition of catecholamine into a biodegradable BMP-2 carrier, in a dose-dependent manner. The expression level of alkaline phosphatase (ALP) in ST2 cells was consistently elevated by BMP-2 and was further elevated by the addition of catecholamine. Catecholamines might play a part in the regulation of bone metabolism in exercise and sports activities through elevation of the plasma level of catecholamine.
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