Identification of endogenous stem cells of the intervertebral disc in degeneration and treatment applications
| Project/Area Number |
20791056
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokai University |
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Principal Investigator |
SAKAI Daisuke Tokai University, 医学部, 講師 (10408007)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 整形外科学 / 脊椎脊髄病学 / 椎間板 / 再生医療 / 幹細胞 / 脊椎 / 髄核細胞 / ニッチ / 椎間板変性 / 脊椎外科 / 前駆細胞 / 再生医学 |
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| Research Abstract |
Heterogeneity of nucleus pulposus cells was revealed in various animal species including human. Endogenous stem/progenitor cells were identified in the intervertebral disc tissue. Its immaturity correlated negatively with age in humans showing that number of endogenous stem cell populations in the inetervertebral disc decrease with aging. Exogenous stem cells did not supply cells to the degenerated intervertebral disc showing that in the inetervertebral disc, exogenous mobilization of cells is extremely difficult. These facts rationalize the idea of supplying cells through external access.
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Report
(3 results)
Research Products
(21 results)
