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Identification of molecular mechanism of excitement with inhalational anesthetics

Research Project

Project/Area Number 20791096
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionJikei University School of Medicine

Principal Investigator

YASUI Yutaka (2008, 2010)  Jikei University School of Medicine, 医学部, 助教 (80459651)

安井 豊 (2009)  Jikei University School of Medicine, 医学部, 助教 (80459601)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords吸入麻酔薬 / 青斑核 / 興奮 / 青斑
Research Abstract

The purpose of the present study is to identify the molecular mechanism of the excitement with the inhalational anesthetics. According to the membrane potential recordings of locus coeruleus neurons, it was shown that PKC took part in the excitement of locus coeruleus caused by sevoflurane. Moreover, the behavioral analysis device was made, and the behavior of the rat was expressed numerically. Interestingly, the order in generating inward current for three volatile anesthetics (sevoflurane, isoflurane and halothane), especially the fact that the inward current with sevoflurane was larger than that with halothane, is in complete accord with the behavioral studies showing that sevoflurane provokes the agitation at the strongest in the rat among these anesthetics. The excitatory current activated by sevoflurane in LC neurons might be one of the potential cellular mechanisms underlying paradoxical excitatory effect of sevoflurane.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (13 results)

  • [Journal Article] Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.2010

    • Author(s)
      R.Aoyama, Y.Okada, S.Yokota, Y.Yasui, K.Fukuda, Y.Shinozaki, H.Yoshida, M.Nakamura, K.Chiba, Y.Yasui, F.Kato, Y.Toyama.
    • Journal Title

      Pain. (in press).

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of particle-associated pulmonary aspiration with bronchoscopic lavage: report of two cases.2009

    • Author(s)
      Yasui, Y, Kida, K, Ohtani, N, Aida, S, Masaki, E.
    • Journal Title

      Eur J Anaesthesiol. 26(6)

      Pages: 527-529

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of particle-associated pulmonary aspiration with bronchoscopic lavage : report of two cases2009

    • Author(s)
      Yasui, Y
    • Journal Title

      European journal of anaesthesiology 26

      Pages: 527-529

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery.2008

    • Author(s)
      K Kida, N Ohtani, K Shoji, Y Yasui, E Masaki.
    • Journal Title

      European Journal of Anaesthesiology. 25

      Pages: 869-875

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery.2008

    • Author(s)
      Ohtani N, Kida K, Shoji K, Yasui Y, Masaki E.
    • Journal Title

      Anesth Analg. 107(6)

      Pages: 1871-1874

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] セボフルランによるラット青斑核ニューロンの直接的興奮2008

    • Author(s)
      安井豊
    • Journal Title

      Anesthesia Network Vol.12

      Pages: 44-49

    • Related Report
      2010 Final Research Report
  • [Journal Article] セボフルランによるラット青斑核ニューロンの直接的興奮2008

    • Author(s)
      安井豊
    • Journal Title

      Anesthesia Network 12

      Pages: 44-49

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Recovery profiles from dexmedetomidine as a general anesthetic adjuvant in patients undergoing lower abdominal surgery2008

    • Author(s)
      Ohtani N
    • Journal Title

      AnesthesiaandAnalgesia 107

      Pages: 1871-1874

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative pain status after intraoperative systemic dexmedetomidine and epidural neostigmine in patients undergoing lower abdominal surgery2008

    • Author(s)
      Kida K
    • Journal Title

      European journal of anaesthesiology 25

      Pages: 869-875

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 根津武彦受傷時の呼吸停止から呼吸器離脱に至った高位頚髄損傷の-症例2011

    • Author(s)
      安井豊、藤原千江子、宮崎愛佳、松田祐典、飯田瑠梨
    • Organizer
      第38回日本集中治療医学会学術集会:DP-79-2
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 受傷時の呼吸停止から呼吸器離脱に至った高位頚髄損傷の一症例2011

    • Author(s)
      安井豊
    • Organizer
      第38回日本集中治療医学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Efficacy of Intrathecal Esmolol on Heat Evoked Responses in a Postoperative Pain Model2010

    • Author(s)
      N.Ohtani, Y.Tachibana, A.Aoi, Y.Yasui, E.Masaki.
    • Organizer
      2010 American society of anesthesiologists Annual Meeting : A288
    • Place of Presentation
      2010 San Diego, CA
    • Year and Date
      2010-10-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Efficacy of Intrathecal Esmolol on Heat Evoked Responses in a Postope rative Pain Model2010

    • Author(s)
      Norimasa Ohtani
    • Organizer
      2010 American society of anesthesiologists Annual Meeting
    • Place of Presentation
      San Diego, CA, U.S.A.
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 導入及び覚醒時興奮のメカニズムを求めて-セボフルレンによる青斑核ニューロンの興奮Molecular and cellular mechanisms of anesthetic-induced agitation S03-062010

    • Author(s)
      安井豊
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 導入及び覚醒時興奮のメカニズムを求めて-セボフルレンによる青斑核ニューロンの興奮2010

    • Author(s)
      安井豊
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2度の全身麻酔下手術後に味覚障害が生じた1症例2010

    • Author(s)
      藤原千江子、藤井輝之、斉藤千恵、小崎佑吾、安井豊、生田目英樹、根津武彦
    • Organizer
      第37回日本集中治療医学会学術集会:DP-42-1
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Perioperative Infusion of Dexmedetomidine at High Dose Reduces Postoperative Analgesic Requirement2008

    • Author(s)
      N.Ohtani, K.Kida, Y.Yasui, K.Shoji, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A552
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Intraoperative Infusion of Dexmedetomidine Decreases Postoperative Pain Scores : A Meta-Analysis2008

    • Author(s)
      Kotaro Kida
    • Organizer
      2008 American society of anesthesiologists Annual Meeting
    • Place of Presentation
      Orlando, FL, U.S.A.
    • Year and Date
      2008-10-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Intraoperative Infusion of Dexmedetomidine Decreases Postoperative Pain Scores:A Meta-Analysis2008

    • Author(s)
      K.Kida, Y.Yasui, N.Ohtani, N.Kuratani, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A1625
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] Dexmedetomidine Counteracts the Excitatory Effect of Sevoflurane on LC2008

    • Author(s)
      Yutaka Yasui
    • Organizer
      2008 American society of anesthesiologists Annual Meeting
    • Place of Presentation
      Orlando, FL, U.S.A.
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Perioperative Infusion of Dexmedetomidine at High Dose Reduces Posto perative Analgesic Requirement2008

    • Author(s)
      Norimasa Ohtani
    • Organizer
      2008 American society of anesthesiologists Annual Meeting
    • Place of Presentation
      Orlando, FL, U.S.A.
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Dexmedetomidine Counteracts the Excitatory Effect of Sevoflurane on LC Neurons of the Rat2008

    • Author(s)
      Y.Yasui, Y.Okamoto, K.Shoji, F.Kato, E.Masaki.
    • Organizer
      2008 American society of anesthesiologists Annual Meeting:A718
    • Place of Presentation
      Orlando, FL
    • Year and Date
      2008-10-18
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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