Identification of molecular mechanism of excitement with inhalational anesthetics
| Project/Area Number |
20791096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
YASUI Yutaka (2008, 2010) Jikei University School of Medicine, 医学部, 助教 (80459651)
安井 豊 (2009) Jikei University School of Medicine, 医学部, 助教 (80459601)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 吸入麻酔薬 / 青斑核 / 興奮 / 青斑 |
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| Research Abstract |
The purpose of the present study is to identify the molecular mechanism of the excitement with the inhalational anesthetics. According to the membrane potential recordings of locus coeruleus neurons, it was shown that PKC took part in the excitement of locus coeruleus caused by sevoflurane. Moreover, the behavioral analysis device was made, and the behavior of the rat was expressed numerically. Interestingly, the order in generating inward current for three volatile anesthetics (sevoflurane, isoflurane and halothane), especially the fact that the inward current with sevoflurane was larger than that with halothane, is in complete accord with the behavioral studies showing that sevoflurane provokes the agitation at the strongest in the rat among these anesthetics. The excitatory current activated by sevoflurane in LC neurons might be one of the potential cellular mechanisms underlying paradoxical excitatory effect of sevoflurane.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn.2010
Author(s)
R.Aoyama, Y.Okada, S.Yokota, Y.Yasui, K.Fukuda, Y.Shinozaki, H.Yoshida, M.Nakamura, K.Chiba, Y.Yasui, F.Kato, Y.Toyama.
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Journal Title
Related Report
Peer Reviewed
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