Interaction with genetics and environmental exposures with prostate cancer and urothelial cancer
| Project/Area Number |
20791114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
TSUKINO Hiromasa University of Miyazaki, 医学部, 助教 (60433059)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 前立腺癌 / 環境 / 遺伝子多型 / 尿路上皮癌 |
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| Research Abstract |
Prostatic carcinogenesis is a complex, multistep, multifactorial process. Like many malignancies, this cancer is the result of interactions between genetic factors of the host and environmental factors. One of the proposed mechanisms involves oxidative DNA damage caused by reactive oxygen species (ROS). Base excision repair (BER) is a very important mechanism for repairing oxidative DNA damage. Human oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing 1 (XRCC1) are enzyme genes of BER. We studied the effect of hOGG1 codon 326 and XRCC1 codon 399 on prostate cancer susceptibility in a case control study of 168 prostate cancer patients and 172 male controls, to determine whether this polymorphism is a biomarker for the risk of prostate cancer. We found no association between hOGG1 codon 326 or XRCC1 codon 399 polymorphisms and occurrence of prostate cancer in Japanese populations.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Skeletal-related events in urological cancer patients with bone metastasis : a multicenter study in Japan.2010
Author(s)
Yokomizo A, Koga H, Shinohara N, Miyahara T, Machida N, Tsukino H, Uozumi J, Nishiyama K, Satoh F, Sakai H, Naito S.
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Journal Title
Int J Urol. 17(4)
Pages: 332-336
NAID
Related Report
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[Journal Article] Population-based study of asymptomatic infection with Chlamydia trachomatis among female and male students.2010
Author(s)
Imai H, Nakao H, Shinohara H, Fujii Y, Tsukino H, Hamasuna R, Osada Y, Fukushima K, Inamori M, Ikenoue T, Katoh T.
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Journal Title
Int J STD AIDS. 21(5)
Pages: 362-366
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[Presentation] 尿路変更術2008
Author(s)
月野浩昌
Organizer
第24回九州ストーマリハビリテーション研究会
Place of Presentation
宮崎
Year and Date
2008-11-15
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