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Interaction with genetics and environmental exposures with prostate cancer and urothelial cancer

Research Project

Project/Area Number 20791114
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionUniversity of Miyazaki

Principal Investigator

TSUKINO Hiromasa  University of Miyazaki, 医学部, 助教 (60433059)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords前立腺癌 / 環境 / 遺伝子多型 / 尿路上皮癌
Research Abstract

Prostatic carcinogenesis is a complex, multistep, multifactorial process. Like many malignancies, this cancer is the result of interactions between genetic factors of the host and environmental factors. One of the proposed mechanisms involves oxidative DNA damage caused by reactive oxygen species (ROS). Base excision repair (BER) is a very important mechanism for repairing oxidative DNA damage. Human oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing 1 (XRCC1) are enzyme genes of BER. We studied the effect of hOGG1 codon 326 and XRCC1 codon 399 on prostate cancer susceptibility in a case control study of 168 prostate cancer patients and 172 male controls, to determine whether this polymorphism is a biomarker for the risk of prostate cancer. We found no association between hOGG1 codon 326 or XRCC1 codon 399 polymorphisms and occurrence of prostate cancer in Japanese populations.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 2 results) Presentation (18 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Skeletal-related events in urological cancer patients with bone metastasis : a multicenter study in Japan.2010

    • Author(s)
      Yokomizo A, Koga H, Shinohara N, Miyahara T, Machida N, Tsukino H, Uozumi J, Nishiyama K, Satoh F, Sakai H, Naito S.
    • Journal Title

      Int J Urol. 17(4)

      Pages: 332-336

    • NAID

      10027257950

    • Related Report
      2010 Final Research Report
  • [Journal Article] Population-based study of asymptomatic infection with Chlamydia trachomatis among female and male students.2010

    • Author(s)
      Imai H, Nakao H, Shinohara H, Fujii Y, Tsukino H, Hamasuna R, Osada Y, Fukushima K, Inamori M, Ikenoue T, Katoh T.
    • Journal Title

      Int J STD AIDS. 21(5)

      Pages: 362-366

    • Related Report
      2010 Final Research Report
  • [Journal Article] f-TUL後に敗血症をきたし治療にエンドトキシン吸着療法を要した1例2010

    • Author(s)
      杉江悟、柴田憲彦、月野浩昌、上村敏雄、賀本敏行
    • Journal Title

      西日本泌尿器科 72

      Pages: 242-246

    • NAID

      10026434018

    • Related Report
      2010 Final Research Report
  • [Journal Article] Urogenital infections.2010

    • Author(s)
      Hamasuna R, Tsukino H.Urethritis.
    • Journal Title

      Editon 2010.European Association of Urology.

      Pages: 777-803

    • Related Report
      2010 Final Research Report
  • [Journal Article] PSA監視療法中の経過観察方法は?また、積極的治療開始基準について教えてください.前立腺癌診療.こんなときどうするQ&A2010

    • Author(s)
      月野浩昌、賀本敏行
    • Journal Title

      中外医学社

      Pages: 227-230

    • Related Report
      2010 Final Research Report
  • [Journal Article] S.Skeletal-related events in urological cancer patients with bone metastasis : a multicenter study in Japan.2010

    • Author(s)
      Yokomizo A, et al.
    • Journal Title

      International Journal of Urology

      Volume: 17 Pages: 332-336

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population-based study of asymptomatic infection with Chlamydia trachomatis among female and male students.2010

    • Author(s)
      Imai H, et al.
    • Journal Title

      International Journal of STD & AIDS

      Volume: 21 Pages: 362-366

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum level of macrophage colony-stimulating factor is increased in prostate cancer patients with bone metastasis.2008

    • Author(s)
      Ide H, Hatake K, Terado Y, Tsukino H, Okegawa T, Nutahara K, Higashihara E, Horie S.
    • Journal Title

      Hum Cell. 21(1)

      Pages: 1-6

    • Related Report
      2010 Final Research Report
  • [Journal Article] 小児原発性膀胱尿管逆流症の治療方針2008

    • Author(s)
      長野正史、上村敏雄、月野浩昌、長田幸夫
    • Journal Title

      西日本泌尿器科 70

      Pages: 183-186

    • NAID

      10026145680

    • Related Report
      2010 Final Research Report
  • [Journal Article] Prevalence of Mycoplasma genitalium among female students in vocational schools in Japan.2008

    • Author(s)
      Hamasuna R, Imai H, Tsukino H, Jensen JS, Osada Y.
    • Journal Title

      Sex Transm Infect. 84(4)

      Pages: 303-305

    • Related Report
      2010 Final Research Report
  • [Presentation] 前立腺肥大症「"がん"との関係は?治療は?」2011

    • Author(s)
      月野浩昌
    • Organizer
      市民公開講座
    • Place of Presentation
      宮崎
    • Year and Date
      2011-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] ホルモン抵抗性前立腺癌に対するドセタキセル療法の検討2010

    • Author(s)
      月野浩昌、鬼塚千衣、下村貴宏、向井尚一郎、賀本敏行
    • Organizer
      第26回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-12-12
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 「Miu-NET」について2010

    • Author(s)
      月野浩昌
    • Organizer
      第161回宮崎県泌尿器科医会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 宮崎県泌尿器科医療連携(Miu-NET)におけるPSAパス2010

    • Author(s)
      月野浩昌
    • Organizer
      第160回宮崎県泌尿器科医会
    • Place of Presentation
      宮崎
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ホルモン抵抗性前立腺癌に対するドセタキセル療法の検討2010

    • Author(s)
      月野浩昌、鬼塚千衣、下村貴宏、向井尚一郎、賀本敏行
    • Organizer
      第62回日本泌尿器科学会西日本総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-05
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 当院における腎癌手術症例の臨床的検討2010

    • Author(s)
      月野浩昌、永井崇敬、鬼塚千衣、下村貴宏、向井尚一郎、上村敏雄、分田裕順、長野正史、井上勝己、野瀬清孝、賀本敏行
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 悪性転化を伴った精巣腫瘍後腹膜リンパ節転移の1例2010

    • Author(s)
      月野浩昌、向井尚一郎、賀本敏行、竹原俊幸、前田幸志郎、小川修
    • Organizer
      日本泌尿器科学会福岡地方会第285回例会
    • Place of Presentation
      久留米
    • Year and Date
      2010-02-06
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 腎adenosarcomaの1例2009

    • Author(s)
      月野浩昌、蓮井良浩、鬼塚千衣、下村貴宏、向井尚一郎、上村敏雄、分田裕順、長野正史、井上勝巳、野瀬清孝、賀本敏行
    • Organizer
      第61回日本泌尿器科学会西日本総会
    • Place of Presentation
      高松
    • Year and Date
      2009-11-07
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 当院における腎盂尿管癌症例の膀胱内再発に関する臨床的検討2009

    • Author(s)
      月野浩昌、向井尚一郎、分田裕順、蓮井良浩、賀本敏行
    • Organizer
      第47回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 当院における腎盂尿管癌症例の膀胱内再発に関する臨床的検討.2009

    • Author(s)
      月野浩昌
    • Organizer
      第47回日本癌治療学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 悪性褐色細胞腫の1例2009

    • Author(s)
      月野浩昌、山口秀樹、向井尚一郎、分田裕順、蓮井良浩、賀本敏行
    • Organizer
      日本泌尿器科学会福岡地方会第284回例会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 悪性褐色細胞腫の1例.2009

    • Author(s)
      月野浩昌
    • Organizer
      日本泌尿器科学会福岡地方会第284回例会
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 当院における腎盂尿管癌症例の臨床的検討2009

    • Author(s)
      月野浩昌、鬼塚千衣、別納弘法、下村貴宏、向井尚一郎、上村敏雄、分田裕順、井上勝己、野瀬清孝、濱砂良一、蓮井良浩
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 当院における腎盂尿管癌症例の臨床的検討.2009

    • Author(s)
      月野浩昌
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱小細胞癌の1例2009

    • Author(s)
      月野浩昌、向井尚一郎、上村敏雄、分田裕順、蓮井良浩
    • Organizer
      日本泌尿器科学会福岡地方会第283回例会
    • Place of Presentation
      北九州
    • Year and Date
      2009-02-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 尿路変更術2008

    • Author(s)
      月野浩昌
    • Organizer
      第24回九州ストーマリハビリテーション研究会
    • Place of Presentation
      宮崎
    • Year and Date
      2008-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 浸潤性膀胱癌症例における前立腺浸潤の臨床病理学的検討2008

    • Author(s)
      月野浩昌、向井尚一郎、片岡寛章、蓮井良浩
    • Organizer
      第46回日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] 浸潤性膀胱癌に対する膀胱全摘除術の臨床的検討2008

    • Author(s)
      月野浩昌、蓮井良浩、上別府豊治、鬼塚千衣、山内正倫、別納弘法、上村敏雄、分田裕順、長野正史、井上勝己、野瀬清孝、濱砂良一、長田幸夫
    • Organizer
      第96回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-26
    • Related Report
      2010 Final Research Report
  • [Book] 前立腺癌診療.こんなときどうするQ&A2010

    • Author(s)
      筧義行
    • Total Pages
      251
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report
  • [Book] Urogenital infections. Editon 20102010

    • Author(s)
      Naber KG, et al.
    • Total Pages
      1182
    • Publisher
      European Association of Urology
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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