Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma

• Project/Area Number: 20791120
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: Iwate Medical University
• Principal Investigator: OBARA Wataru Iwate Medical University, 医学部, 講師 (90337155)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 進行性腎細胞癌 / 活性型ビタミンD3 / 抗腫瘍効果 / 個別化医療 / 活性型ビタミンD / 進行性腎癌

Research Abstract

The exogenous vitamin D had no effect for normal kidney cell and showed the activation of the vitamin D metabolic pathway with activity of CYP24. Vitamin D3 had the suppression of the renal carcinoma cell proliferation and the mechanism of action was caused by induction of apoptosis and the cell cycle arrest. Activity of CYP24 also increased by combination of molecular target medicine and vitamin D3 and showed augmentation of the cytostatic effect.

Research Products

• [Journal Article] Sutudy of the predidion system for clinical response to M-VAC neoadjuvant chemotherapy for bladder cancer. (2010)
  • Author(s): Takata R., Obara W., Fujioka T.
  • Journal Title: Actuelle Urol Volume: 41 Pages: 41-45
  • Peer Reviewed
• [Journal Article] Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors. (2010)
  • Author(s): Akimoto C, Ueda T, Inoue K, Yamaoka I, Sakari M, Obara W, Fujioka T, Nagahara A, Nonomura N, Tsutsumi S, Aburatani H, Miki T, Matsumoto T, Kitagawa H, Kato S
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 19891-6
  • Peer Reviewed
• [Journal Article] Evidence-based clinical practice guidelines for renal cell carcinoma (Summary-JUA 2007 Edition). (2009)
  • Author(s): Fujioka T, Obara W.
  • Journal Title: Int J Urol 16 Pages: 339-353
  • NAID: 10025197247
• [Journal Article] Evidence-based Ginical practice guidelines for renal cell carcinoma (Summary-JUA 2007 Edition). (2009)
  • Author(s): Fujioka T, Obara W
  • Journal Title: Int J Urol 16 Pages: 339-353
  • Peer Reviewed
• [Journal Article] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinoma. (2008)
  • Author(s): Obara W, Mizutani Y, Oyama C, Akaza H, Ishii N, Kohri K, Namiki M, Okuyama A, Shima H, Yokoyama M, Shuin T, Miki T, Watanabe Y, Fujioka T.
  • Journal Title: Int J Urol 15 Pages: 794-799
• [Journal Article] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinom (2008)
  • Author(s): Obara W, et.al.
  • Journal Title: Int J Ural 15・9 Pages: 794-799
  • Peer Reviewed
• [Journal Article] 後腹膜鏡下腎尿管摘除術を施行した回腸導管造設後の右腎孟腫瘍 (2008)
  • Author(s): 井筒俊利、小原航、大澤泰介、加藤香廉、近田龍一郎、藤岡知昭
  • Journal Title: 臨床泌尿器科 62・5 Pages: 327-330
  • Peer Reviewed
• [Journal Article] Prognostic significance of vitamin D receptor and retinoid X receptor expression in renal cell carcinoma. (2007)
  • Author(s): Obara W, Konda R, Akasaka S, Nakamura S, Sugawara A, Fujioka T.
  • Journal Title: J Urol. 178 Pages: 1497-503
• [Journal Article] Vitamin D receptor gene polymorphisms are associated with increased risk and progression of renal cell carcinoma in a Japanese population. (2007)
  • Author(s): Obara W, Suzuki Y, Kato K, Tanji S, Konda R, Fujioka T.
  • Journal Title: Int J Urol. 14 Pages: 483-487
• [Presentation] Phase I Clinical Trial of novel HIG2 derived epitope peptide vaccine treatment for kidney cancer (2010)
  • Author(s): Obara W
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: Sanfrancisco, USA
• [Presentation] Clinical trial of novel HLA-A24 restricted DEPDC1 and MPHOSPH1 Peptide Vaccine for Bladder Cancer (2010)
  • Author(s): Obara W
  • Organizer: 第9回アジア臨床腫瘍学会学術集会
  • Place of Presentation: 岐阜
• [Presentation] Phase I dinical trial of vaccination of MPHOSHP1 and DEPDC1 epitope peptidevaccine for patients with bladder cancer (2009)
  • Author(s): Obara W
  • Organizer: アメリカ泌尿器科学会
  • Place of Presentation: シカゴ
• [Presentation] Current surgical treatment for prostate and bladder cancer in Japan, including attempt of novel peptide vacane treatment (2009)
  • Author(s): Obara W
  • Organizer: 第47回日本癌治療学会
  • Place of Presentation: 横浜
• [Book] EBM癌化学療法-分子標的治療法2011-2012 (2010)
  • Author(s): 小原航, 藤岡知昭
  • Total Pages: 6
  • Publisher: 中外医学社
• [Book] インフォームドコンセントのための図解シリーズ17.膀胱癌 (2010)
  • Author(s): 小原航, 藤岡知昭(監修:吉田修,編集:大園誠一郎, 赤座英之)
  • Total Pages: 8
  • Publisher: 医薬ジャーナル
• [Book] Urologic Surgery-6尿路変更術・尿路再建術Psoas hitch法 (2010)
  • Author(s): 小原航, 丹治進, 藤岡知昭
  • Total Pages: 8
  • Publisher: MEDICAL VIEW
• [Book] 腎・泌尿器癌-基礎・臨床研究のアップデート I.腎癌 臨床研究 診断 腎癌診療ガイドライン (2010)
  • Author(s): 小原航, 藤岡知昭
  • Total Pages: 6
  • Publisher: 日本臨床
• [Book] 腎・泌尿器癌-基礎・臨床研究のアップデート I.腎癌 臨床研究 治療 腎癌の分子標的治療 その他の分子標的薬 (2010)
  • Author(s): 小原航, 藤岡知昭
  • Total Pages: 4
  • Publisher: 日本臨床
• [Book] がんペプチドワクチン療法腎がん新規腫瘍抗原(HIG2)を利用したワクチン療法 (2009)
  • Author(s): 小原航、高田亮、兼平貢、藤岡知昭(中村祐輔編)
  • Total Pages: 5
  • Publisher: 中山書店
• [Book] Renal Cell Carcinoma (2008)
  • Author(s): Obara W, Fujioka T.
  • Total Pages: 6
  • Publisher: Can To Kagaku Ryouho
• [Book] 【尿路上皮癌の診断と治療Update】膀胱癌組織の遺伝子発現解析によるMVACネオアジュバント化学療法の効果予測 (2008)
  • Author(s): 高田亮、片桐豊雅、兼平貢、小原航、中村祐輔、藤岡知昭
  • Total Pages: 4
  • Publisher: Urology View
• [Remarks] ホームページ等