Elucidation of the antitumor effect with active form vitamin D3 and the individualized medicine for the progressive renal cell carcinoma
| Project/Area Number |
20791120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OBARA Wataru Iwate Medical University, 医学部, 講師 (90337155)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 進行性腎細胞癌 / 活性型ビタミンD3 / 抗腫瘍効果 / 個別化医療 / 活性型ビタミンD / 進行性腎癌 |
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| Research Abstract |
The exogenous vitamin D had no effect for normal kidney cell and showed the activation of the vitamin D metabolic pathway with activity of CYP24. Vitamin D3 had the suppression of the renal carcinoma cell proliferation and the mechanism of action was caused by induction of apoptosis and the cell cycle arrest. Activity of CYP24 also increased by combination of molecular target medicine and vitamin D3 and showed augmentation of the cytostatic effect.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Testis-specific protein on Y chromosome (TSPY) represses the activity of the androgen receptor in androgen-dependent testicular germ-cell tumors.2010
Author(s)
Akimoto C, Ueda T, Inoue K, Yamaoka I, Sakari M, Obara W, Fujioka T, Nagahara A, Nonomura N, Tsutsumi S, Aburatani H, Miki T, Matsumoto T, Kitagawa H, Kato S
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 19891-6
Related Report
Peer Reviewed
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[Journal Article] Prospective study of combined treatment with interferon-alpha and active vitamin D3 for Japanese patients with metastatic renal cell carcinoma.2008
Author(s)
Obara W, Mizutani Y, Oyama C, Akaza H, Ishii N, Kohri K, Namiki M, Okuyama A, Shima H, Yokoyama M, Shuin T, Miki T, Watanabe Y, Fujioka T.
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Journal Title
Int J Urol 15
Pages: 794-799
Related Report
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