| Project/Area Number |
20791150
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
YAMASAKI Kentaro Nagasaki University, 大学院・医歯薬総合研究科, 助教 (90380899)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 生殖医学 / マイクロキメリズム / 自己免疫疾患 / 強皮症 |
|---|
| Research Abstract |
Fetal microchimerism is derived from cell transfers between mother and the fetus during pregnancy. We evaluated the relationship with fetal microchimerism and autoimmune diseases. We performed quantitative PCR which targeted Y-chromosome specific genes in cell free DNAs in plasmas of autoimmune disease patients and RT-PCR which targeted Y-chromosome specific genes in their blood. The PCR products targeted to DYS1 gene were detected from cell free DNA in systemic sclerosis patients, but not in other autoimmune diseases. There was relationships between microchimerism and systemic sclerosis, however other autoimmune diseases which contains systemic lupus, antiphospholipid antibody syndrome.
|
