Expression analysis of micro-RNAs in inner ear.
| Project/Area Number |
20791187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shinshu University |
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Principal Investigator |
NISHIO Shinya Shinshu University, 医学部, 研究員 (70467166)
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| Co-Investigator(Renkei-kenkyūsha) |
USAMI Shinichi 信州大学, 医学部, 教授 (10184996)
TAKUMI Yutaka 信州大学, 医学部, 准教授 (70312501)
SUZUKI Nobuyoshi 信州大学, 医学部附属病院, 助教 (20377641)
HASHIMOTO Shigenari 信州大学, 医学部附属病院, 助教 (90359729)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子 / 難聴 / 内耳 / 聴覚 / マイクロRNA / 遺伝子発現パターン |
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| Research Abstract |
In this study, we examined the expressions of microRNAs in the inner ear of the senescence-accelerated model (SAM-P1) mouse and its control strain using microRNA microarray to understand the microRNAs role in the maintenance of hearing function and the mechanism of age-related hearing impairment. We identified microRNAs highly expressed in mouse cochleae. Interestingly, miR-96, miR-182 and miR-183, which are proposed as important factors for inner ear development and function, were deceased by about half in 20-week-old SAM-P1 mice, revealing an age-related hearing loss phenotype.
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Report
(4 results)
Research Products
(4 results)
