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Regeneration study of olfactory bulb neurons using bone marrow stem cells

Research Project

Project/Area Number 20791196
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

YOSHINOBU Junko  Okayama University, 医学部, 技術専門職員 (80448224)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生医学 / 細胞・組織 / 脳・神経
Research Abstract

The regenerative therapy using bone marrow stem cells progressing remarkably in late years is expected as a new therapy for severe olfaction disorder that recovery is difficult by the current medical care. This study was conducted to examine the efficacy of the regenerative therapy using bone marrow cells in regeneration of olfactory bulb said to be more difficult than olfactory epithelium. As a result, it was found that the regenerative therapy using bone marrow cells had potential as a new therapy for not only the disorder of olfactory epithelium but also the disorder of olfactory bulb. Also, it was suggested that the use of cytokine raised efficacy of the regenerative therapy more.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Prolactin may stimulate proliferation in the olfactory epithelium of the female mouse2009

    • Author(s)
      Orita S, Yoshinobu J, Orita Y, Tsujigiwa H, Kakiuchi M, Nagatsuka H, Nomiya S, Nagai N, Nishizaki K
    • Journal Title

      Am J Rhinol Allergy 23(2)

      Pages: 135-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The engraftment of transplanted bone marrow - derived cells into the inner ear2009

    • Author(s)
      rita Y, Tsujigiwa H, Nishizaki K, Teshima T, Yoshinobu J, Orita S, Takeuchi A, Takeda Y, Nagatsuka H, Naga N
    • Journal Title

      Eur Arch Otorhinolary 266(1)

      Pages: 59-63

    • Related Report
      2009 Final Research Report
  • [Journal Article] Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse2008

    • Author(s)
      Borkosky SS, Nagatsuka H, Orita Y, Tsujigiwa H, Yoshinobu J, Gunduz M, Rodriguez AP, Missana LR, Nishizaki K, Nagai N
    • Journal Title

      Biocell 32(3)

      Pages: 251-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] G-CSFを用いた嗅上皮傷害時における骨髄細胞の取り込み率の検討2008

    • Author(s)
      吉延潤子
    • Organizer
      第47回日本鼻科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-09-26
    • Related Report
      2009 Final Research Report 2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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