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The study of mucosal immunity in murine allergic rhinitis model

Research Project

Project/Area Number 20791206
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionKagoshima University

Principal Investigator

TANAKA Norimitsu  Kagoshima University, 大学院・医歯学総合研究科, 助教 (90404483)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords鼻アレルギー / マウスモデル / 粘膜免疫 / Th1 / Th2バランス / 分泌型IgA / 舌下免疫療法
Research Abstract

Phosphorylcholine (PC), which is a structural component of wide variety of bacteria, inhibits the allergic response in the upper respiratory tract in murine allergic rhinitis model. PC-pretreated mice showed mild allergic nasal symptoms. The levels of total IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was inhibited by PC-pretreatment. Thus, PC might be useful for the development of new immunotherapeutic strategies of allergic disease.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008

All Presentation (13 results)

  • [Presentation] Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airway infections.2009

    • Author(s)
      Norimitsu Tanaka
    • Organizer
      14th International congress of mucosal immunology
    • Place of Presentation
      Boston, USA
    • Year and Date
      2009-07-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airaway infections.2009

    • Author(s)
      Norimitu Tanaka
    • Organizer
      14^<th> International congress of mucosal immunology
    • Place of Presentation
      ボストン(アメリカ合衆国)
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mucosal and systemic immune responses induced by sublingual immunization with phosphorylcholine.2009

    • Author(s)
      Norimitsu Tanaka
    • Organizer
      6th Extraordinary international symposium on recent advances in otitis media
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Mucosal and systemic immune response induced by sublingual immunization with phosphorylcholine.2009

    • Author(s)
      Norimitu Tanaka
    • Organizer
      6^<th> Extraordinary international symposium on recent advances in otitis media.
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2009-05-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Phosphorylcholine経鼻・舌下投与における免疫応答の相違点2009

    • Author(s)
      田中紀充、早水佳子、宮下圭一、福山聡、黒野祐一
    • Organizer
      第27回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      千葉市
    • Related Report
      2009 Final Research Report
  • [Presentation] Phosphorylcholine(PC)経鼻・舌下投与における免疫応答の相違点2009

    • Author(s)
      田中紀充
    • Organizer
      第27回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      三井ガーデンホテル千葉(千葉市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中耳炎予防を目的としPhosphorylcholine舌下ワクチンにおける粘膜免疫応答の観察2008

    • Author(s)
      田中紀充、宮下圭一、黒野祐一
    • Organizer
      第18回日本耳科学会総会・学術講演会
    • Place of Presentation
      神戸市
    • Related Report
      2009 Final Research Report
  • [Presentation] 市シンポジウム:口腔・咽頭-免疫療法の新たなルートとしての有用性とメカニズム-「上気道感染症に対する舌下粘膜ワクチンの有用性」2008

    • Author(s)
      田中紀充、黒野祐一
    • Organizer
      第21回日本口腔咽頭科学会総会・学術講演会
    • Place of Presentation
      鹿児島
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗原舌下投与による鼻粘膜抗原特異的粘膜免疫応答2008

    • Author(s)
      田中紀充、宮下圭一、早水佳子、福岩達哉、福山聡、黒野祐一
    • Organizer
      第109回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Mucosal and systemic immune responses induced by sublingual immunization with phosphorycholine2008

    • Author(s)
      N. Tanaka
    • Organizer
      The 12^<th> Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗原舌下投与による鼻粘膜抗原特異的粘膜免疫応答2008

    • Author(s)
      田中紀充
    • Organizer
      第109回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 上気道感染症に対する舌下粘膜ワクチンの有用性2008

    • Author(s)
      田中紀充
    • Organizer
      第21回日本口腔・咽頭科学会
    • Place of Presentation
      城山観光ホテル(鹿児島市)
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中耳炎予防を目的としたPhosphorylcoline舌下ワクチンにおける粘膜免疫応答の観察2008

    • Author(s)
      田中紀充
    • Organizer
      第18回日本耳科学会総会・学術講演会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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