The study of mucosal immunity in murine allergic rhinitis model

• Project/Area Number: 20791206
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kagoshima University
• Principal Investigator: TANAKA Norimitsu Kagoshima University, 大学院・医歯学総合研究科, 助教 (90404483)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 鼻アレルギー / マウスモデル / 粘膜免疫 / Th1 / Th2バランス / 分泌型IgA / 舌下免疫療法

Research Abstract

Phosphorylcholine (PC), which is a structural component of wide variety of bacteria, inhibits the allergic response in the upper respiratory tract in murine allergic rhinitis model. PC-pretreated mice showed mild allergic nasal symptoms. The levels of total IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was inhibited by PC-pretreatment. Thus, PC might be useful for the development of new immunotherapeutic strategies of allergic disease.

Research Products

• [Presentation] Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airway infections. (2009)
  • Author(s): Norimitsu Tanaka
  • Organizer: 14th International congress of mucosal immunology
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-08
• [Presentation] Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airaway infections. (2009)
  • Author(s): Norimitu Tanaka
  • Organizer: 14^<th> International congress of mucosal immunology
  • Place of Presentation: ボストン(アメリカ合衆国)
  • Year and Date: 2009-07-08
• [Presentation] Mucosal and systemic immune responses induced by sublingual immunization with phosphorylcholine. (2009)
  • Author(s): Norimitsu Tanaka
  • Organizer: 6th Extraordinary international symposium on recent advances in otitis media
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-08
• [Presentation] Mucosal and systemic immune response induced by sublingual immunization with phosphorylcholine. (2009)
  • Author(s): Norimitu Tanaka
  • Organizer: 6^<th> Extraordinary international symposium on recent advances in otitis media.
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2009-05-08
• [Presentation] Phosphorylcholine経鼻・舌下投与における免疫応答の相違点 (2009)
  • Author(s): 田中紀充、早水佳子、宮下圭一、福山聡、黒野祐一
  • Organizer: 第27回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 千葉市
• [Presentation] Phosphorylcholine(PC)経鼻・舌下投与における免疫応答の相違点 (2009)
  • Author(s): 田中紀充
  • Organizer: 第27回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 三井ガーデンホテル千葉(千葉市)
• [Presentation] 中耳炎予防を目的としPhosphorylcholine舌下ワクチンにおける粘膜免疫応答の観察 (2008)
  • Author(s): 田中紀充、宮下圭一、黒野祐一
  • Organizer: 第18回日本耳科学会総会・学術講演会
  • Place of Presentation: 神戸市
• [Presentation] 市シンポジウム:口腔・咽頭-免疫療法の新たなルートとしての有用性とメカニズム-「上気道感染症に対する舌下粘膜ワクチンの有用性」 (2008)
  • Author(s): 田中紀充、黒野祐一
  • Organizer: 第21回日本口腔咽頭科学会総会・学術講演会
  • Place of Presentation: 鹿児島
• [Presentation] 抗原舌下投与による鼻粘膜抗原特異的粘膜免疫応答 (2008)
  • Author(s): 田中紀充、宮下圭一、早水佳子、福岩達哉、福山聡、黒野祐一
  • Organizer: 第109回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 大阪
• [Presentation] Mucosal and systemic immune responses induced by sublingual immunization with phosphorycholine (2008)
  • Author(s): N. Tanaka
  • Organizer: The 12^<th> Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: 奈良県新公会堂(奈良市)
• [Presentation] 抗原舌下投与による鼻粘膜抗原特異的粘膜免疫応答 (2008)
  • Author(s): 田中紀充
  • Organizer: 第109回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 大阪国際会議場(大阪市)
• [Presentation] 上気道感染症に対する舌下粘膜ワクチンの有用性 (2008)
  • Author(s): 田中紀充
  • Organizer: 第21回日本口腔・咽頭科学会
  • Place of Presentation: 城山観光ホテル(鹿児島市)
• [Presentation] 中耳炎予防を目的としたPhosphorylcoline舌下ワクチンにおける粘膜免疫応答の観察 (2008)
  • Author(s): 田中紀充
  • Organizer: 第18回日本耳科学会総会・学術講演会
  • Place of Presentation: 神戸国際会議場(神戸市)