The study of mucosal immunity in murine allergic rhinitis model
| Project/Area Number |
20791206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kagoshima University |
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Principal Investigator |
TANAKA Norimitsu Kagoshima University, 大学院・医歯学総合研究科, 助教 (90404483)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 鼻アレルギー / マウスモデル / 粘膜免疫 / Th1 / Th2バランス / 分泌型IgA / 舌下免疫療法 |
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| Research Abstract |
Phosphorylcholine (PC), which is a structural component of wide variety of bacteria, inhibits the allergic response in the upper respiratory tract in murine allergic rhinitis model. PC-pretreated mice showed mild allergic nasal symptoms. The levels of total IgE were significantly lower in PC-pretreated mice. The IL-4 production by splenic CD4+ T cells was inhibited by PC-pretreatment. Thus, PC might be useful for the development of new immunotherapeutic strategies of allergic disease.
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Report
(3 results)
Research Products
(13 results)
