Epithelial-Mesenchymal Transition of Retinal Pigment Epithelium in Age-related Macular Degeneration in SOD1 dificient mice.

• Project/Area Number: 20791269
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: HIRASAWA Manabu Keio University, 医学部, 助教 (80365345)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 加齢黄斑変性 / 上皮間葉移行 / 酸化ストレス / 網膜色素上皮 / 転写因子

Research Abstract

We focused on epithelial-mesenchymal transition(EMT)-like changes of retinal pigment epithelium cells(RPE) in age-related macular degeneration(AMD) and observed transcriptional factors relate to EMT. We analyzed age-related changes of retina from SOD1 deficient mice, recognized as oxidative stress model mice, and found out about retinal degeneration with aging and disruption of cell-cell contact of RPE, however, transcriptional factors relate to EMT were not detected in RPE. Otherwise we observed nuclear localization of Snail about RPE from surgically exicised choroidal neovascularization membrane secondary to AMD.

Research Products

• [Journal Article] Secondary macular hole associated with central retinal vein occulusion treated with corticosteroid injection (2009)
  • Author(s): Hirasawa M, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S.
  • Journal Title: Japanese Journal of Ophthalmology 53 Pages: 279-281
  • Peer Reviewed
• [Journal Article] Secondary macular hole associated with central retinal vein occulusion treated with corticosteroid injection. (2009)
  • Author(s): Hirasawa M, et al
  • Journal Title: Japanese Journal of Ophthalmology 53 Pages: 279-281
  • Peer Reviewed
• [Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice (2008)
  • Author(s): Hashizume K, Hirasawa M, Imamura Y, Noda S, Shimizu T, Kurihara T, Noda K, Shinoda K, Ozawa Y, Ishida S, Miyake Y, Shirasawa T, Tsubota K.
  • Journal Title: Am J Pathol 172 Pages: 1325-1331
  • Peer Reviewed
• [Journal Article] 加齢黄斑変性の予防と生活習慣 (2008)
  • Author(s): 平沢学、今村裕
  • Journal Title: 眼科領域におけるアンチエイジング医学 50 Pages: 409-419
• [Journal Article] 加齢黄斑変性動物モデル (2008)
  • Author(s): 平沢学、今村裕
  • Journal Title: 網膜硝子体診療updateIV 第62巻増刊号 Pages: 208-210
• [Journal Article] アンチエイジングサプリメント処方 (2008)
  • Author(s): 平沢学
  • Journal Title: アンチエイジング医学の基礎と臨床 改訂2版 Pages: 268-269
• [Journal Article] Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice (2008)
  • Author(s): Hashizume K Hirasawa M, et.al.
  • Journal Title: American Journal of Pathology 172 Pages: 1325-1331
  • Peer Reviewed
• [Presentation] 緑内障手術後の遷延性脈絡膜剥離 (2009)
  • Author(s): 宮田博、平沢学
  • Organizer: 日本緑内障学会
  • Year and Date: 2009-11-13
• [Presentation] 緑内障手術後における脈絡膜剥離の統計 (2009)
  • Author(s): 宮田博、平沢学
  • Organizer: 日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2009-11-13
• [Presentation] 白内障手術症例におけるα1遮断薬の使用状況 (2009)
  • Author(s): 西別府弘子, 五十嵐俊, 間宮純子, 苗村かおり, 平沢学, 宮田博, 高尾良洋
  • Organizer: 第19回日本医療薬学会年会
  • Year and Date: 2009-10-24
• [Presentation] Age-related changes of gene expression profile in retina of SOD1-deficient mice (2008)
  • Author(s): Hirasawa M, Imamura Y, Hashizume K, Noda K, Ishida S, Tsukamoto N, Kudo-Saitoh C, Kawakami Y, Tsubota K.
  • Organizer: ARVO 2008
• [Presentation] Oxidative Stress Markers in Japanese Patients With Age-Related Macular Degeneration: A Pilot Study (2008)
  • Author(s): Hashizume K, ImamuraY, Hirasawa M, Sawanobori M, Ishida S, Kurosaka D, Tsubota K.
  • Organizer: ARVO 2008
• [Book] メディカルレビュー社、患者さんから浴びせられる眼科疾患100の質問 (2008)
  • Author(s): 平沢学, 他
  • Publisher: メディカルビュー社
• [Book] 他、加齢黄斑変性の患者さんへの指導必須3項目 (2008)
  • Author(s): 平沢学, 他
  • Publisher: 眼科ケアメディカルビュー社