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detecting heterogeneity of neuroblastomas with a whole genetic analysis using SNP array

Research Project

Project/Area Number 20791301
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatric surgery
Research InstitutionKyushu University

Principal Investigator

RYOTA Souzaki  Kyushu University, 大学病院, 医員 (10403990)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経芽腫 / SNPアレイ / 生物学的多様性 / マイクロダイゼクション / SNP array / heterogeniety
Research Abstract

We thought that a small change of dosage of the MYCN gene due to intratumoral heterogeniety and a chromosomal gain of MYCN gene affected the prognosis in neuroblastoma. Therefore, the microdissection and SNP array were performed to determine the dosage of the MYCN gene and we found tha cases with a small number of MYCN amplified cells and a large number of MYCN gain cells. It was thought that a judgment of more accurate MYCN amplification was necessary using LCM and SNP array analysis in future

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2009 2008

All Journal Article (12 results) (of which Peer Reviewed: 8 results) Presentation (13 results)

  • [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japan.2009

    • Author(s)
      Tajiri T, Souzaki R, Kinoshita Y, Tanaka S, Koga Y, Suminoe A, Matsuzaki A, Hara T, Taguchi T
    • Journal Title

      J Pediatr Surg. 44(12)

      Pages: 2253-7

    • Related Report
      2009 Final Research Report
  • [Journal Article] A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT.2009

    • Author(s)
      Kinoshita Y, Souzaki R, Tajiri T, Ieiri S, Hashizume M, Taguchi T
    • Journal Title

      Oncol Rep. 21(4)

      Pages: 881-6

    • Related Report
      2009 Final Research Report
  • [Journal Article] 神経芽腫摘出術後に発症した術後腸重積症の1例2009

    • Author(s)
      宗崎良太, 他
    • Journal Title

      小児がん 46(3)

      Pages: 393-7

    • NAID

      110007359108

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT.2009

    • Author(s)
      Kinoshita Y, et al
    • Journal Title

      Oncol.Rep. 21(4)

      Pages: 881-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risks and benefits of ending of mass screening for neuroblastoma at 6 months of age in Japan.2009

    • Author(s)
      Tajiri T, et al
    • Journal Title

      J Pediatr Surg. 44(12)

      Pages: 2253-7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A preoperative evaluation for neo-infantile liver tumors using a three-dimensional reconstruction of multidetector row CT2009

    • Author(s)
      Kinoshita Y, Souzaki R, et.al
    • Journal Title

      Oncol Rep (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implications of a slight increase in the gene dosage of MYCN in neuroblastoma determined using quantitative PCR.2008

    • Author(s)
      Souzaki R, Tajiri T, Higashi M, Kinoshita Y, Tanaka S, Kohashi K, Tsuneyoshi M, Taguchi T
    • Journal Title

      Pediatr Surg Int. 24(10)

      Pages: 1095-100

    • NAID

      10027863988

    • Related Report
      2009 Final Research Report
  • [Journal Article] Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study.2008

    • Author(s)
      Kinoshita Y, Tajiri T, Souzaki R, Tatsuta K, Higashi M, Izaki T, Takahashi Y, Taguchi T
    • Journal Title

      J Pediatr Hematol Oncol. 30(6)

      Pages: 447-50

    • Related Report
      2009 Final Research Report
  • [Journal Article] Clinical implications of a slight increase in the gene dosage of MYCN in neuroblastoma determined using quantitative PCR2008

    • Author(s)
      Souzaki R, et.al.
    • Journal Title

      Pediatr Surg Int 24(10)

      Pages: 1095-1100

    • NAID

      10027863988

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic value of lectin reactive alpha-fetoprotein for neo-infantile hepatic tumors and malignant germ cell tumors-Preliminary Study-2008

    • Author(s)
      Kinoshita Y, Tajiri T, Souzaki R, et.al
    • Journal Title

      J Pediatr Hematol/Oncol 30

      Pages: 447-450

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 進行神経芽腫治療に対する臓器温存手術と術後体外照射の意義2008

    • Author(s)
      田尻達郎、宗崎良太、木下義晶、田中桜、田口智章
    • Journal Title

      小児外科 40

      Pages: 624-628

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学的予後因子解析からみたマススクリーニングの功罪2008

    • Author(s)
      田尻達郎、宗崎良太、木下義晶、田中桜、東真弓、田口智章
    • Journal Title

      小児外科 40

      Pages: 1047-1053

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] マイクロダイゼクションとSNP arrayを用いた神経芽腫の悪性度の層別化2009

    • Author(s)
      宗崎良太, 他
    • Organizer
      小児がん学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] MYCN gainと2p gain2009

    • Author(s)
      宗崎良太, 他
    • Organizer
      日本小児外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] The correlation between MYCN gain detected by FISH and distal 2p gain detected by SNP array in neuroblastoma2009

    • Author(s)
      Souzaki R, et al
    • Organizer
      Pasific Association of Pediatric surgerons
    • Place of Presentation
      Hongkong
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] FISH法におけるMYC NgainとSNP arrayにおける2p gainの意義2009

    • Author(s)
      宗崎良太、田尻達郎、田中桜、木下義晶、田口智章
    • Organizer
      神経芽腫研究会
    • Place of Presentation
      築地、がんセンター研究所
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] MYCN gainと2p gain2009

    • Author(s)
      宗崎良太, 他
    • Organizer
      第46回日本小児外科学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] The correlation between MYCN gain detected by FISH and distal 2p gain detected by SNP array in neuroblastoma.2009

    • Author(s)
      Souzaki R, et al.
    • Organizer
      Pasific Association of Pediatric surgerons
    • Place of Presentation
      Hongkong
    • Related Report
      2009 Final Research Report
  • [Presentation] マイクロダイゼクションとSNP arrayを用いた神経芽腫の悪性度の層別化.2009

    • Author(s)
      宗崎良太, 他
    • Organizer
      第25回小児がん学会
    • Place of Presentation
      千葉
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経芽腫におけるMYCN増幅、MYCN gain, 2p gainの検討2008

    • Author(s)
      宗崎良太、田尻達郎、田中桜、木下義晶、田口智章
    • Organizer
      第24回小児がん学会
    • Place of Presentation
      千葉県幕張
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 神経芽腫における定量的PCR法で判定されたMYCN遺伝子量微量増加の意義2008

    • Author(s)
      宗崎良太、田尻達郎、田中桜、木下義晶、田口智章
    • Organizer
      第45回日本小児外科学会
    • Place of Presentation
      つくば
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical implications of the slight increase for the gene dosage of MYCN determi ned using quantitative PCR in neuroblastoma2008

    • Author(s)
      Souzaki R, Tajiri T, Kinoshita Y, Tanaka S, Taguchi T
    • Organizer
      13th Advances in Neuroblastoma Research
    • Place of Presentation
      幕張
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Clinical implications of the slight increase for the gene dosage of MYCN determined using quantitative PCR in neuroblastoma.2008

    • Author(s)
      Souzaki R, et al.
    • Organizer
      ANR 2008
    • Place of Presentation
      Makuhari
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経芽腫における定量的PCR法で判定されたMYCN遺伝子量微量増加の意義2008

    • Author(s)
      宗崎良太, 他
    • Organizer
      第45回日本小児外科学会
    • Place of Presentation
      筑波
    • Related Report
      2009 Final Research Report
  • [Presentation] 神経芽腫におけるMYCN増幅、MYCN gain, 2p gainの検討2008

    • Author(s)
      宗崎良太, 他
    • Organizer
      第24回小児がん学会
    • Place of Presentation
      幕張
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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