burn and immunity : the role of alarmin from burn wound

Research Project

Project/Area Number	20791329
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Emergency medicine
Research Institution	Aichi Medical University
Principal Investigator	MORIZANE Ruri Aichi Medical University, 医学部, 助教 (30465520)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	熱傷 / サイトカイン / アラーミン / アデノシン / HMGB1 / alarmin / PAI-1 / DAMPs / 重症熱傷 / 焼痂 / 脾細胞
Research Abstract	An adenosine known as one of the alarmin has a strong anti-inflammatory action. Adenosine inhibits inflammatory cytokine production from monocytes at at μM level. We found that serum adenosine level increased significantly under condition of massive tissue injury like burn. We suggest that released adenosine from injured tissue would have physiological role to regulate excessive inflammation at site of burn wound.

Report

(3 results)