Analysis of raft/caveolae function in osteoclasts

• Project/Area Number: 20791342
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphological basic dentistry
• Research Institution: Meikai University
• Principal Investigator: MASUHARA Masaaki Meikai University, 大学院・医歯学総合研究科, 講師 (70372901)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 破骨細胞 / ラフト / カベオラ / コレステロール

Research Abstract

Disruption of the balance between osteoblastic bone formation and osteoclastic bone resorption causes various bone disorders, such as osteopetrosis and osteoporosis. Some epidemiological works clarify the contribution of lipid metabolism to the bone metabolism, but there are few knowledge about the molecular mechanisms how it concerns. We researched the effects of cholesterol on the osteoclastogenesis, and revealed that regulations of the cytokine signals by raft/caveolae are important in the differentiation of osteoclasts.

Research Products

• [Journal Article] サイトカインと破骨細胞分化におけるシグナル伝達 (2010)
  • Author(s): 増原正明
  • Journal Title: 鹿児島大学歯学部紀要 Vol.30 Pages: 45-53
  • NAID: 120005231978
• [Journal Article] サイトカインと破骨細胞分化におけるシグナル伝達 (2010)
  • Author(s): 増原正明
  • Journal Title: 鹿児島大学歯学部紀要 30 Pages: 45-53
  • NAID: 120005231978
• [Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors. (2009)
  • Author(s): Sato T, Masuhara M, Hada N, Okayasu M, Hakeda Y
  • Journal Title: J. Meikai Dent. Med 38(1) Pages: 1-8
  • NAID: 40016525912
  • Peer Reviewed
• [Journal Article] Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-κB p50/p65. (2009)
  • Author(s): Masuhara M, Sato T, Hada N, Hakeda Y
  • Journal Title: J. Bone Miner. Metab. 27(1) Pages: 46-56
  • NAID: 10025336150
  • Peer Reviewed
• [Journal Article] IFN-ζ/limitin inhibits generation of osteoclast precursors. (2009)
  • Author(s): Sato T, Masuhara M, Hada N, Okayasu M, Hakeda Y
  • Journal Title: J.Meikai Dent.Med. 38 Pages: 1-8
  • NAID: 40016525912
  • Peer Reviewed
• [Journal Article] Protective protein/cathepsin A downregulates osteo clastogenesis by associating with and degrading NFKB p50/p65 (2009)
  • Author(s): Masuhara M, Sato T, Had a N, Hakeda Y
  • Journal Title: J. Bone Miner. Metab. 27(1) Pages: 46-56
  • Peer Reviewed
• [Presentation] りんごの果実と果皮の慢性的経口投与は卵巣摘出マウスの認知と情動に影響を及ぼす (2010)
  • Author(s): 塚原飛央、永山知宏、増原正明、佐藤友昭
  • Organizer: 日本薬理学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-18
• [Presentation] 破骨細胞分化におけるRANKLに依存して発現するcaveolin-1とlipid/raftの役割 (2008)
  • Author(s): 増原正明、佐藤卓也、岡安麻里、羽田直人、金田利夫、羽毛田慈之
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-30
• [Presentation] 破骨細胞前駆細胞においてI型インターフェロンにより発現調節されるmicroRNAの網羅的解析 (2008)
  • Author(s): 佐藤卓也、増原正明、羽田直人、岡安麻里、羽毛田慈之
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-25
• [Presentation] 破骨細胞前駆細胞において1型インターフェロンにより発現調節されるmicroRNAの網羅的解析 (2008)
  • Author(s): 佐藤卓也、増原正明、羽田直人、岡安麻里、羽毛田慈之
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 東京
  • Year and Date: 2008-09-25
• [Presentation] ビタミンB12はマウス破骨細胞形成の必須因子である (2008)
  • Author(s): 真野博、清水純、増原正明、羽毛田慈之、河田哲典、和田政裕
  • Organizer: 日本ビタミン学会
  • Place of Presentation: 仙台
  • Year and Date: 2008-06-14
• [Presentation] 破骨細胞におけるカベオリン-1の機能解析 (2008)
  • Author(s): 増原正明
  • Organizer: 明海歯科医学会
  • Place of Presentation: 埼玉
  • Year and Date: 2008-06-05