Analysis of raft/caveolae function in osteoclasts
| Project/Area Number |
20791342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Meikai University |
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Principal Investigator |
MASUHARA Masaaki Meikai University, 大学院・医歯学総合研究科, 講師 (70372901)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 破骨細胞 / ラフト / カベオラ / コレステロール |
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| Research Abstract |
Disruption of the balance between osteoblastic bone formation and osteoclastic bone resorption causes various bone disorders, such as osteopetrosis and osteoporosis. Some epidemiological works clarify the contribution of lipid metabolism to the bone metabolism, but there are few knowledge about the molecular mechanisms how it concerns. We researched the effects of cholesterol on the osteoclastogenesis, and revealed that regulations of the cytokine signals by raft/caveolae are important in the differentiation of osteoclasts.
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Report
(3 results)
Research Products
(12 results)
