Inhibition of bone resorption by RNA aptamer for immunoregulatory receptor PD-1 induced on activated T cell.

Research Project

Project/Area Number	20791350
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Functional basic dentistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TAKAHASHI Mariko Tokyo Medical and Dental University, 歯学部, 技術職員 (90334440)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	破骨細胞 / PD-1 / RNAアプタマー
Research Abstract	PD-1 is a negative regulator of immune responses. We made a hypothesis that PD-1 is involved in inflammatory bone resorption and that PD-1 signal has possibilities as a drug target which inhibit inflammatory bone resorption. RNA aptamer for PD-1 might be a candidate and thus we tried to make an aptamer. During the research period, it was technically difficult to make the aptamer and to investigate the effect. To get basic knowledge of more effective and safety medical product, it is important to create new drug-discovery technology like an aptamer in the future.

Report

(3 results)