Analysis of the mechanisms between preterm birth and periodontal diseases.

• Project/Area Number: 20791354
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Yamaguchi University
• Principal Investigator: TAKII Ryousuke Yamaguchi University, 大学院・医学系研究科, 助教 (00419558)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 歯科薬理学 / 早産 / 低体重児 / 歯周病 / ジンジパイン / ストレス

Research Abstract

Recent etpidemiological study showed that periodontal disease is a risk factor of preterm birth and low birth weight. Periodontal disease is a chronic inflammatory process and it is thought that the origin is infection by oral bacteria. These results indicate that gingipains inhibitors may be not the medication for periodontal disease, but also the preventive medicine for preterm birth and low birth weight by periodontal disease.

Research Products

• [Journal Article] Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3 (2010)
  • Author(s): Ryosuke Takii, Sachiye Inouye, Mitsuaki Fujimoto, Tamami Nakamura, Toyohide Shinkawa, Ramachandran Prakasam, Ke Tan, Naoki Hayashida, Hitoshi Ichikawa, Tsonwin Hai, Akira Nakai
  • Journal Title: J. Immunol 184 Pages: 1041-1048
  • Peer Reviewed
• [Journal Article] A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock. (2010)
  • Author(s): Mitsuaki Fujimoto, Naoki Hayashida, Takuma Katoh, Kouji Oshima, Toyohide Shinkawa, Ramachandran Prakasam, Ke Tan, Sachiye Inouye, Ryosuke Takii, Akira Nakai.
  • Journal Title: Mol. Biol. Cell 21 Pages: 106-116
  • Peer Reviewed
• [Journal Article] Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3 (2010)
  • Author(s): Takii, et.al
  • Journal Title: J.Immunol 184 Pages: 1041-1041
  • Peer Reviewed
• [Journal Article] A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock (2010)
  • Author(s): Fujimoto, et.al
  • Journal Title: Mot.Biol.Cell 21 Pages: 106-106
  • Peer Reviewed
• [Journal Article] Analysis of HSF4 Binding Regions Reveals Its Necessity for Gene Regulation during Development and Heat Shock Response in Mouse Lenses. (2008)
  • Author(s): Mitsuaki Fujimoto, Koji Oshima, Toyohide Shinkawa, Bei Bei Wang, Sachiye Inouye, Naoki Hayashida, Ryosuke Takii, Akira Nakai
  • Journal Title: J. Biol. Chem. 283 Pages: 29961-29970
  • Peer Reviewed
• [Journal Article] Analysis of HSF4 Binding Regions Reveals Its Necessity for Gene Regulation during Development and Heat Shock Response in Mouse Lenses (2008)
  • Author(s): Fujimoto, et.al.
  • Journal Title: J. Biol. Chem 283 Pages: 29961-29970
  • Peer Reviewed
• [Presentation] 熱ショック転写因子HSF1による炎症性サイトカイン発現の制御機構第32回日本分子生物学会 (2009)
  • Author(s): 瀧井良祐
  • Organizer: 第82回日本生化学会合同年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 熱ショック転写因子HSF1による炎症性サイトカイン発現の制御機構 (2009)
  • Author(s): 瀧井良祐
  • Organizer: 第32回日本分子生物学会、第82回日本生化学会合同年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 温熱ストレスによる炎症性サイトカイン発現の抑制機構第31回日本分子生物学会 (2008)
  • Author(s): 瀧井良祐
  • Organizer: 第81回日本生化学会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] 温熱ストレスによる炎症性サイトカイン発現の抑制機構 (2008)
  • Author(s): 瀧井良祐
  • Organizer: 第31回日本分子生物学会、第81回日本生化学会合同年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10