| Project/Area Number |
20791374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SOENO Yuuichi The Nippon Dental University, 生命歯学部, 講師 (70350139)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 実験腫瘍学 / 歯学 / 病理学 / ノンコーディングRNA / ホスト遺伝子 / snoRNA / rRNA / リンパ腫 / ノックアウトマウス |
|---|
| Research Abstract |
To elucidate the not-yet-known function of U50 snoRNA we generated an mU50-deficient mouse line. In this mouse line, mU50-targeted methylations on the rRNA were reduced as with the reduction of mU50 expression. The mU50-deficient mice were indistinguishable from wild-type littermates at sight, but some of those animals were prone to have defects in lymphatic organs. Regarding to the strong U50 expression in hematopoietic lineages, promoter analyses revealed the involvement of c-MYC and BCL6 in the transcription of the host-gene.
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