Biomaterials immunization using a novel peptide that binds to a PMMA denture

Research Project

Project/Area Number	20791415
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Prosthetic dentistry
Research Institution	Tohoku University
Principal Investigator	KEN-ICHIRO Komaki Tohoku University, 病院, 助教 (40361109)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	PMMA / ペプチド / インターフェイス / バイオマテリアル
Research Abstract	We used a peptide library for iolating peptide aptamers against PMMA powder. We observed that 7 of 18 phages displayed on their surfaces peptides having the identical sequence. We confirmed that the predominant phage retained the ability to bind to PMMA powder and also PMMA plate. The binding of biomolecules that bring active biological function to the surface of PMMA is critical clinically. Using fusion proteins of the iolated peptide motif and functional biomolecule, we expect to add the ability to immunize on PMMA surface.