Participation of influence and active oxygen that change in oral environment gives to cell death in hippocampus CA1・CA3 area

• Project/Area Number: 20791445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: AOKI Hiromichi Kanagawa Dental College, 顎口腔機能修復科学講座クラウンブリッジ補綴学分野, 助教 (50350533)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 活性酸素 / アンモン角 / 細胞死 / 口腔環境の変化

Research Abstract

As for the signal attenuation of MC-PROXYL of soft chewing group, a significant difference was admitted for control. Moreover, a significant difference was admitted between soft chewing group and the Mix group. The tendency with a lot of 8OHdG positive cells was admitted in soft chewing group and the molar extraction group compared with the control group.

Research Products

• [Journal Article] Molarless condition suppresses proliferation but not differentiation rates into neurons in the rat dentate gyrus (2010)
  • Author(s): H. Aoki, K. Kimoto, N. Hori, N. Hoshi, T. Yamamoto, M. Onozuka
  • Journal Title: Neuroscience Letters 469 Pages: 44-48
• [Journal Article] Molarless condition suppresses proliferation but not differentiation rates into neurons in the rat dentate gyrus (2010)
  • Author(s): H.Aoki
  • Journal Title: Neuroscience Letters 469 Pages: 44-48
  • Peer Reviewed
• [Presentation] 咀嚼機能不全による海馬神経新生への影響 (2009)
  • Author(s): 青木宏道
  • Organizer: 日本補綴歯科学会第118回学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2009-06-06
• [Presentation] Neurogenesis in the rat hippocampus dysfunctional mastication (2009)
  • Author(s): H.Aoki
  • Organizer: 6th AAP Congress of the Asian Academy of Prosthodontics
  • Place of Presentation: SOEUL KOREA
  • Year and Date: 2009-04-25
• [Presentation] 咀嚼機能不全による海馬神経新生への影響 (2009)
  • Author(s): 青木宏道、堀紀雄、川畑政綱、木本克彦
  • Organizer: 日本補綴歯科学会第118回学術大会
  • Place of Presentation: 京都
• [Presentation] Neurogenesis in the rat hippocampus by dysfunctional mastication (2008)
  • Author(s): 青木宏道
  • Organizer: 再生補綴医学研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] Neurogenesis in the rat hippocampal formation under the c onditions of dysfunctional mastication (2008)
  • Author(s): 青木宏道
  • Organizer: IADR
  • Place of Presentation: カナダトロント
• [Presentation] Neurogenesis in the rat hippocampus by dysfunctional mastication
  • Author(s): H. Aoki N. Hori, K. Kimoto
  • Organizer: 6th AAP Congress of the Asian Academy of Prosthodontics Seoul Korea
  • Place of Presentation: Seoul Korea