Regeneration Therapy of Salivary gland with using Tissue Engineering

• Project/Area Number: 20791464
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nagoya University
• Principal Investigator: TAKAYUKI Sugito Nagoya University, 大学院・医学系研究科, COE研究員 (50467297)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 再生医療 / 幹細胞 / 唾液腺 / 浮遊培養 / 3次元培養

Research Abstract

Our normal cultured salivary gland cells possess a morphological potential. On the other hand, we found that, it is difficult to culture normal salivary gland cells on three dimensional polyvinyl alcohol (PVA) with using our radial-flow bioreactor. This result indicates that we need optimize a scaffold and flow volume in radial-flow bioreactor.

Research Products

• [Journal Article] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation (2009)
  • Author(s): Sugito T、Mineshiba F、Zheng C、Cotrim AP、Goldsmith CM、Baum BJ
  • Journal Title: Oral Diseases Vol.15、No.1 Pages: 76-81
  • Peer Reviewed
• [Journal Article] Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands (2009)
  • Author(s): Zheng C、Cotrim AP、Sunshine AN、Sugito T、Liu L、Sowers A、Mitchell JB、Baum BJ
  • Journal Title: Clin Cancer Res Vol.15、No.14 Pages: 4641-8
  • Peer Reviewed
• [Journal Article] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation. (2009)
  • Author(s): Sugito Takayuki
  • Journal Title: Oral Diseases 15,1 Pages: 76-81
  • Peer Reviewed
• [Journal Article] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation (2008)
  • Author(s): Sugito Takayuki
  • Journal Title: Oral Diseases 15, 1 Pages: 76-81
  • Peer Reviewed
• [Presentation] サル培養唾液腺細胞を用いた人工唾液腺作成のための研究 (2010)
  • Author(s): 杉戸孝行
  • Organizer: Aichi Sjogren's Syndrome Confernce 12^<th> Meeting
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-25
• [Presentation] サル培養唾液腺細胞を用いた人工唾液腺作成のための研究 (2010)
  • Author(s): 杉戸孝行
  • Organizer: Aichi Sjogren's Syndrome Confernce 12th Meeting
  • Place of Presentation: 名古屋
  • Year and Date: 2010-02-15
• [Presentation] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation (2009)
  • Author(s): 杉戸孝行
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation (2008)
  • Author(s): Sugito T
  • Organizer: International Conference on Frontiers of Dental and Craniofacial Research
  • Place of Presentation: 中華人民共和国、北京
  • Year and Date: 2008-11-02
• [Presentation] Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation (2008)
  • Author(s): Sugito Takayuki
  • Organizer: International Conference on Frontiers of Dental and Craniofacial Research
  • Place of Presentation: 中華人民共和国北京
  • Year and Date: 2008-11-02