Development of a newly medical device for periodontaltissue regeneration using brain-derived neurotrophic factor(BDNF) / hyaluronic acid complex

• Project/Area Number: 20791466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TAKEDA Katsuhiro Hiroshima University, 医歯薬学総合研究科, 助教 (10452591)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 再生歯学 / 脳由来神経栄養因子 / 高分子ヒアルロン酸 / 歯周組織再生

Research Abstract

In this study, we evaluated the efficacy of synthesized high molecular weight hyaluronic acid gel (HA) as a BDNF carrier in the class III furcation defects of beagle dogs.
In BDNF/HA groups, the denuded root surface was almost completely covered with new cementum and the periodontal ligament separated the regenerated bone from the cementum with an adequate width. The combination of BDNF and hyaluronic acid gel may have high potential for periodontal tissue regeneration in clinical usage.

Research Products

• [Journal Article] Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death (2009)
  • Author(s): Kajiya M, Shiba H, Fujita T, Takeda K, Uchida Y, Kawaguchi H, Kitagawa M, Takata T, Kurihara H
  • Journal Title: J Cell Physiol 221(3) Pages: 696-706
  • Peer Reviewed
• [Journal Article] Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts (2008)
  • Author(s): Kajiya M., Shiba H., Fujita T., Ouhara K., Takeda K., Mizuno N., Kawaguchi H., Kitagawa M., Takata T., Tsuji K., Kurihara H
  • Journal Title: J Biol Chem 283(23) Pages: 16259-67
  • Peer Reviewed
• [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発-高分子ヒアルロン酸のヒト歯周靭帯細胞に及ぼす影響- (2009)
  • Author(s): 武田克浩、永原隆吉、柴秀樹、藤田剛、松田真司、河口浩之、橋本正道、辻紘一郎、栗原英見
  • Organizer: 第131回秋季日本歯科保存学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-10-29
• [Presentation] 脳由来神経栄養因子(BDNF)と高分子ピアルロン酸を用いた歯周組織再生療法の開発-高分子ピアルロン酸のヒト歯周靭帯細胞に及ぼす影響- (2009)
  • Author(s): 武田克浩
  • Organizer: 第129回秋季日本歯科保存学会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-10-29
• [Presentation] K. TAKEDA, N SAKAI, H. SHIBA, H. KAWAGUCHI, K TSUJI, H. KURIHARA (2009)
  • Author(s): K. TAKEDA, N SAKAI, H. SHIBA, H. KAWAGUCHI, K TSUJI, H
  • Organizer: 87th General Session & Exhibition of the International Association for Dental Research
  • Place of Presentation: (Miami), USA
  • Year and Date: 2009-04-03
• [Presentation] Brain-derived Neurotrophic Factor/Hyaluronic Acid Complex Enhances Periodontal Tissue Regeneration (2009)
  • Author(s): 武田克浩
  • Organizer: 87th General session and Exhibition of the international association for dental research
  • Place of Presentation: Miami, USA
  • Year and Date: 2009-04-03
• [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発 (2008)
  • Author(s): 坂井宣之, 武田克浩, 柴秀樹, 河口浩之, 橋本正道, 辻紘一郎, 栗原英見
  • Organizer: 日本歯科医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-11-14
• [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発 (2008)
  • Author(s): 武田克浩
  • Organizer: 第21回日本歯科医学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-11-14
• [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発-β-TCP併用効果の検討- (2008)
  • Author(s): 武田克浩
  • Organizer: 第129回秋季日本歯科保存学会
  • Place of Presentation: 富山市
  • Year and Date: 2008-11-06
• [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発 (2008)
  • Author(s): 坂井宣之, 武田克浩, 柴秀樹, 河口浩之, 橋本正道, 辻紘一郎, 栗原英見
  • Organizer: 第51回春季日本歯周病学会学術大会
  • Place of Presentation: 大宮
  • Year and Date: 2008-10-19
• [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発-根面処理併用効果の検討- (2008)
  • Author(s): 武田克浩
  • Organizer: 第51回秋季日本歯周病学会
  • Place of Presentation: 四日市市
  • Year and Date: 2008-10-19
• [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発 (2008)
  • Author(s): 武田克浩
  • Organizer: 第51回春季日本歯周病学会
  • Place of Presentation: 大宮市
  • Year and Date: 2008-04-24
• [Presentation] BDNF/hyaluronic acid enhances periodontal tissue regeneration (2008)
  • Author(s): Sakai, N., Kurihara, H., Takeda, K., Shiba, H., Kawaguchi, H
  • Organizer: 86th General Session & Exhibition of the International Association for Dental Research (Toronto)
  • Place of Presentation: (Toronto), Canada