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Development of a newly medical device for periodontaltissue regeneration using brain-derived neurotrophic factor(BDNF) / hyaluronic acid complex

Research Project

Project/Area Number 20791466
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionHiroshima University

Principal Investigator

TAKEDA Katsuhiro  Hiroshima University, 医歯薬学総合研究科, 助教 (10452591)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords再生歯学 / 脳由来神経栄養因子 / 高分子ヒアルロン酸 / 歯周組織再生
Research Abstract

In this study, we evaluated the efficacy of synthesized high molecular weight hyaluronic acid gel (HA) as a BDNF carrier in the class III furcation defects of beagle dogs.
In BDNF/HA groups, the denuded root surface was almost completely covered with new cementum and the periodontal ligament separated the regenerated bone from the cementum with an adequate width. The combination of BDNF and hyaluronic acid gel may have high potential for periodontal tissue regeneration in clinical usage.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)

  • [Journal Article] Brain-derived neurotrophic factor protects cementoblasts from serum starvation-induced cell death2009

    • Author(s)
      Kajiya M, Shiba H, Fujita T, Takeda K, Uchida Y, Kawaguchi H, Kitagawa M, Takata T, Kurihara H
    • Journal Title

      J Cell Physiol 221(3)

      Pages: 696-706

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts2008

    • Author(s)
      Kajiya M., Shiba H., Fujita T., Ouhara K., Takeda K., Mizuno N., Kawaguchi H., Kitagawa M., Takata T., Tsuji K., Kurihara H
    • Journal Title

      J Biol Chem 283(23)

      Pages: 16259-67

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発-高分子ヒアルロン酸のヒト歯周靭帯細胞に及ぼす影響-2009

    • Author(s)
      武田克浩、永原隆吉、柴秀樹、藤田剛、松田真司、河口浩之、橋本正道、辻紘一郎、栗原英見
    • Organizer
      第131回秋季日本歯科保存学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ピアルロン酸を用いた歯周組織再生療法の開発-高分子ピアルロン酸のヒト歯周靭帯細胞に及ぼす影響-2009

    • Author(s)
      武田克浩
    • Organizer
      第129回秋季日本歯科保存学会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] K. TAKEDA, N SAKAI, H. SHIBA, H. KAWAGUCHI, K TSUJI, H. KURIHARA2009

    • Author(s)
      K. TAKEDA, N SAKAI, H. SHIBA, H. KAWAGUCHI, K TSUJI, H
    • Organizer
      87th General Session & Exhibition of the International Association for Dental Research
    • Place of Presentation
      (Miami), USA
    • Year and Date
      2009-04-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Brain-derived Neurotrophic Factor/Hyaluronic Acid Complex Enhances Periodontal Tissue Regeneration2009

    • Author(s)
      武田克浩
    • Organizer
      87th General session and Exhibition of the international association for dental research
    • Place of Presentation
      Miami, USA
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発2008

    • Author(s)
      坂井宣之, 武田克浩, 柴秀樹, 河口浩之, 橋本正道, 辻紘一郎, 栗原英見
    • Organizer
      日本歯科医学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-11-14
    • Related Report
      2009 Final Research Report
  • [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発2008

    • Author(s)
      武田克浩
    • Organizer
      第21回日本歯科医学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発-β-TCP併用効果の検討-2008

    • Author(s)
      武田克浩
    • Organizer
      第129回秋季日本歯科保存学会
    • Place of Presentation
      富山市
    • Year and Date
      2008-11-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発2008

    • Author(s)
      坂井宣之, 武田克浩, 柴秀樹, 河口浩之, 橋本正道, 辻紘一郎, 栗原英見
    • Organizer
      第51回春季日本歯周病学会学術大会
    • Place of Presentation
      大宮
    • Year and Date
      2008-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] BDNFと高分子ヒアルロン酸を用いた歯周組織再生療法の開発-根面処理併用効果の検討-2008

    • Author(s)
      武田克浩
    • Organizer
      第51回秋季日本歯周病学会
    • Place of Presentation
      四日市市
    • Year and Date
      2008-10-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 脳由来神経栄養因子(BDNF)と高分子ヒアルロン酸を用いた歯周組織再生療法の開発2008

    • Author(s)
      武田克浩
    • Organizer
      第51回春季日本歯周病学会
    • Place of Presentation
      大宮市
    • Year and Date
      2008-04-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] BDNF/hyaluronic acid enhances periodontal tissue regeneration2008

    • Author(s)
      Sakai, N., Kurihara, H., Takeda, K., Shiba, H., Kawaguchi, H
    • Organizer
      86th General Session & Exhibition of the International Association for Dental Research (Toronto)
    • Place of Presentation
      (Toronto), Canada
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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