Investigation of the mechanism of osteocalcin expression and VEGF induction in human dental pulp cells.

• Project/Area Number: 20791504
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Gifu University
• Principal Investigator: HATAKEYAMA Daijiro Gifu University, 医学系研究科, 助教 (60377653)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯髄組織幹細胞 / オステオカルシン / 血管内皮増殖因子 / 誘導機構の解析 / 歯胚組織幹細胞 / 組織幹細胞 / VEGF

Research Abstract

Bone morphogenetic protein -2, -4 induces osteocalcin expression and vascular endothelial growth factor accumulation via p38 and p44/p42 mitogen activated protein kinases in human osteoblastic cells induced by human dental pulp stem cells. Moreover, it is suggested that the expression levels of vascular endothelial growth factor are very high in oliginal human dental pulp stem cells.

Research Products

• [Remarks] ホームページ等