Investigation of physiological role of maspin on the maintenance of integeity of articular cartilage and the possibility of maspin as a novel therapeutic agent for arthritis
| Project/Area Number |
20791526
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TOKUYAMA Reiko The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 助教 (20380090)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | マスピン / TGF-β / セリンプロテアーゼインヒビター / 関節軟骨 / 関節炎 / 関節炎治療薬 / DDS |
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| Research Abstract |
Maspin is a serine protease inhibitor. Little is known on maspin expression on akeletal and cartilage tissue. In this study, we confirmed that maspin was expressed on chondrocyte of articular cartilage. Moreover, after injection of anti-maspin antibody into knee joints of rats, articular cartilage tissues were destructed following inflammatory reactions. Then, recombinant maspin protein injection may prevent the destruction of tissues by arthritis. To elucidate this, more focused studies will be necessary in the future.
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Report
(3 results)
Research Products
(7 results)
