Study on the mechanism of malignant transformation of oral leukoplakia mediated by p63 and Notch signaling pathway

• Project/Area Number: 20791531
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kyushu University
• Principal Investigator: KAWANO Shintaro Kyushu University, 歯学研究院, 助教 (00398067)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔扁平上皮癌 / 癌化 / 白板症 / p63 / Notchシグナル / 分化 / 上皮間葉転換 / 上皮異形成 / 癌幹細胞 / 口腔白板症

Research Abstract

This study was addressed to reveal the molecular mechanisms of malignant transformation of oral leukoplakia (OL) into squamous cell carcinoma (OSCC). In the OL, LI of p63 increased significantly according to the severity of epithelial dysplasia, though that of Notch1 decreased. p63-LI in the OL with malignant transformation was significantly higher than that in the OL without. In the OSCC, these LIs increased significantly in association with the histologic grade. Increased ΔNp63 expression was possibly involved in malignant transformation in epithelial dysplasia and proliferation and differentiation of OSCC.

Research Products

• [Journal Article] 著明な嚢胞形成を伴った顎下腺多形腺腫の1例 (2011)
  • Author(s): 後藤雄一、川野真太郎、大部一成、鈴木華子、松原良太、清末崇裕、小林家吉、白土雄司、中村誠司
  • Journal Title: 日本口腔腫瘍学会誌 23 Pages: 17-23
  • NAID: 10030795907
• [Journal Article] 著明な嚢胞形成を伴った顎下腺多形腺腫の1例 (2011)
  • Author(s): 後藤雄一, 川野真太郎, 大部一成, 鈴木華子, 松原良太, 清末崇裕, 小林家吉, 白土雄司, 中村誠司
  • Journal Title: 日本口腔腫瘍学会誌 Volume: 23 Pages: 17-23
  • NAID: 10030795907
  • Peer Reviewed
• [Journal Article] 潔舌可動部亜全摘症例に対するリハビリテーションとその治療効果-下顎歯槽堤形成術と最大舌圧の経時的変化- (2010)
  • Author(s): 松山美和、大部一成、川野真太郎、松下恭之、中村誠司、古谷野
  • Journal Title: 顎顔面補綴 33 Pages: 15-22
• [Journal Article] 舌可動部亜全摘症例に対するリハビリテーションとその治療効果-下顎歯槽堤形成術と最大舌圧の経時的変化- (2010)
  • Author(s): 松山美和, 大部一成, 川野真太郎, 松下恭之, 中村誠司, 古谷野潔
  • Journal Title: 顎顔面補綴 Volume: 33 Pages: 15-22
  • NAID: 10029056710
  • Peer Reviewed
• [Journal Article] An anti-apoptotic role of NF-κ B in TNF α-induced apoptosis in amelo blastoma cell line (2008)
  • Author(s): L.Hendarmin, S. Kawano, et.al.
  • Journal Title: Oral Science International 5 Pages: 96-103
  • NAID: 10027107171
  • Peer Reviewed
• [Journal Article] 副耳下腺に生じた多形腺腫の1例 (2008)
  • Author(s): 見立英史、大部一成, ら
  • Journal Title: 日本口腔腫瘍学会雑誌 20 Pages: 291-296
  • Peer Reviewed
• [Journal Article] Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings European Radiology
  • Author(s): Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga,Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura
  • Journal Title: in press
• [Journal Article] 舌下腺に発生した多形腺腫の1例
  • Author(s): 川野真太郎、鈴木華子、松原良太、清末崇裕、清島保、中村誠司
  • Journal Title: 日本口腔外科学会雑誌 印刷中
  • NAID: 10030272193
• [Presentation] Possible involvement of ΔNp63 in proliferation and differetiation of OSCC (2010)
  • Author(s): Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Nakao, Y., Toyoshima, T., Kakehashi, H., Kitamura, R., Yoshiga, D., Oobu, K., Nakamura, S
  • Organizer: 10th Biennial Congress of the European Association of Oral Medicine
  • Year and Date: 2010-09-23
• [Presentation] Immunohistochemical localization of p75NTR in oral leukoplakia and OSCC (2010)
  • Author(s): Kiyosue, T., Kawano, S., Matsubara, R., Goto, Y., Nakao, Y., Toyoshima, T., Kakehashi, H., Kitamura, R., Yoshiga, D., Oobu, K., Nakamura, S
  • Organizer: 10th Biennial Congress of the European Association of Oral Medicine
  • Year and Date: 2010-09-23
• [Presentation] Immunohistochemical analysis of cytokeratin 17 in oral squamous cell carcinoma (2010)
  • Author(s): Kitamura R., Toyoshima T., Kawano S., Oobu K., Kiyosue T., Matsubara R., Goto Y., Nakamura S.
  • Organizer: 10th Biennial Congress of the European Association of Oral Medicine
  • Year and Date: 2010-09-23
• [Presentation] Resistant factors of the conservative therapy to BRONJ (2010)
  • Author(s): Goto Y., Kawano S., Hayashida J., Ikari T., Kurahara S., Toyoshima T., Minamizato T., Kiyosue T ., Matsubara R., Oobu K., Takenoshita Y., Mori Y., Shiratsuchi Y., Nakamura S.
  • Organizer: 10th Biennial Congress of the European Association of Oral Medicine
  • Year and Date: 2010-09-23
• [Presentation] Evaluating the effect of preoperative chemoradiotherapy using a pharmacokinetic analysis of dynamic contrast enhanced MR imaging ( 1 ) (2010)
  • Author(s): Toru Chikui, Shintaro Kawano, Yoshio Matsuo, Syunya Sunami, Takeshi Kamitani, Syozou Koga, Kazunori Yoshiura
  • Organizer: 23rd Annual Meeting of European Society of Head and Neck Radiology
  • Year and Date: 2010-09-09
• [Presentation] Evaluating the effect of preoperative chemoradiotherapy using a pharmacokinetic analysis of dynamic contrast enhanced MR imaging (2) (2010)
  • Author(s): Toru Chikui, Shintaro Kawano, Yoshio Matsuo, Syunya Sunami, Takeshi Kamitani, Syozou Koga, Masahiro Ooga, Kazunori Yoshiura
  • Organizer: 23rd Annual Meeting of European Society of Head and Neck Radiology
  • Year and Date: 2010-09-09
• [Presentation] 口腔白板症および口腔扁平上皮癌における上皮幹細胞マーカー(p63、P75NTR)の発現 (2009)
  • Author(s): 松原良太、川野真太郎, ら
  • Organizer: 第54回日本口腔外科学会総会
  • Place of Presentation: 札幌市
  • Year and Date: 2009-10-10
• [Presentation] Results of Surgical Treatment for Stages I and II Tongue Squamous Cell Carcinoma (2008)
  • Author(s): Shintaro KAWANO, Yu NAKAO, Takahiro KIYOSUE, Ryota MATSUBARA, Yuichi GOTO, Kazunari OOBU, Seiji NAKAMURA
  • Organizer: XIX Congress of the European Association for Cranio-Maxillo-Facial- Surgery
  • Year and Date: 2008-09-09
• [Presentation] Clinical evaluation of FDG-PET for oral malignant tumors (2008)
  • Author(s): Ryota MATSUBARA, Shintaro KAWANO, Kazunari OOBU, Toru CHIKUI, Yu NAKAO, Takahiro KIYOSUE, Yuichi GOTO, Yuji SHIRATUCHI, Seiji NAKAMURA
  • Organizer: XIX Congress of the European Association for Cranio-Maxillo-Facial- Surgery
  • Year and Date: 2008-09-09
• [Presentation] Results of Surgical Treatment for Stages I and II Tongue Squamous Cell Carcinomas (2008)
  • Author(s): S. Kawano, et.al.
  • Organizer: XIX Congress of the European Association for Cranio-Maxillo-Facial-Surgery
  • Place of Presentation: Italy, Bologna
  • Year and Date: 2008-09-09
• [Remarks]
  • URL: http://hyoka.ofc.kyushu-u.ac.jp/search/index.html