Study on the mechanism of malignant transformation of oral leukoplakia mediated by p63 and Notch signaling pathway
| Project/Area Number |
20791531
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KAWANO Shintaro Kyushu University, 歯学研究院, 助教 (00398067)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 口腔扁平上皮癌 / 癌化 / 白板症 / p63 / Notchシグナル / 分化 / 上皮間葉転換 / 上皮異形成 / 癌幹細胞 / 口腔白板症 |
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| Research Abstract |
This study was addressed to reveal the molecular mechanisms of malignant transformation of oral leukoplakia (OL) into squamous cell carcinoma (OSCC). In the OL, LI of p63 increased significantly according to the severity of epithelial dysplasia, though that of Notch1 decreased. p63-LI in the OL with malignant transformation was significantly higher than that in the OL without. In the OSCC, these LIs increased significantly in association with the histologic grade. Increased ΔNp63 expression was possibly involved in malignant transformation in epithelial dysplasia and proliferation and differentiation of OSCC.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings European Radiology
Author(s)
Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga,Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura
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Journal Title
Related Report
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[Presentation] Possible involvement of ΔNp63 in proliferation and differetiation of OSCC2010
Author(s)
Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Nakao, Y., Toyoshima, T., Kakehashi, H., Kitamura, R., Yoshiga, D., Oobu, K., Nakamura, S
Organizer
10th Biennial Congress of the European Association of Oral Medicine
Year and Date
2010-09-23
Related Report
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[Presentation] Immunohistochemical localization of p75NTR in oral leukoplakia and OSCC2010
Author(s)
Kiyosue, T., Kawano, S., Matsubara, R., Goto, Y., Nakao, Y., Toyoshima, T., Kakehashi, H., Kitamura, R., Yoshiga, D., Oobu, K., Nakamura, S
Organizer
10th Biennial Congress of the European Association of Oral Medicine
Year and Date
2010-09-23
Related Report
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[Presentation] Resistant factors of the conservative therapy to BRONJ2010
Author(s)
Goto Y., Kawano S., Hayashida J., Ikari T., Kurahara S., Toyoshima T., Minamizato T., Kiyosue T ., Matsubara R., Oobu K., Takenoshita Y., Mori Y., Shiratsuchi Y., Nakamura S.
Organizer
10th Biennial Congress of the European Association of Oral Medicine
Year and Date
2010-09-23
Related Report
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