Roles of Odz3 in primary cartilage during mandibular condylar development

• Project/Area Number: 20791565
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: TAKESHITA Nobuo Tohoku University, 大学院・歯学研究科, 助教 (50431515)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Odz3 / 下顎頭 / 軟骨 / ATDC5 / 0dz3 / 軟骨細胞

Research Abstract

Mandibular condyle has been speculated to develop by differentiation of fibroblast-like cells covering the condyle to chondrocytes ; however, the developmental mechanisms have not been revealed. We used laser-captured microdissection and cDNA microarray analysis to obtain the genes highly expressed in fibroblast-like cells ; one of these genes was Odz3. The temporal and spatial expression of Odz3 mRNA was revealed in mandibular condylar cartilage during early developmental stage in mice and ATDC5 cells, a mouse chondrogenic cell line. These findings suggest that Odz3 might act as a regulatory factor in the early developmental stage of mandibular condylar cartilage.

Research Products

• [Journal Article] Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse. (2009)
  • Author(s): Williams JA, Kondo N, Okabe T, Takeshita N, Pilchak DM, Koyama E, Ochiai T, Jensen D, Chu ML, Kane MA, Napoli JL, Enomoto-Iwamoto M, Ghyselinck N, Chambon P, Pacifici M, Iwamoto M
  • Journal Title: Dev Biol. 328 Pages: 315-327
  • Peer Reviewed
• [Presentation] Ten-m/Odz3 is expressed in chondrogenic process during mandibular fracture healing (2009)
  • Author(s): Tomohiro Fukunaga
  • Organizer: 87^<th> International Association for Dental Research
  • Place of Presentation: Miami, USA
• [Presentation] 下顎頭の軟骨細胞分化におけるOdz3の役割 (2008)
  • Author(s): 竹下信郎, 村上隆, 福永智広, 山城隆, 宮脇正一, 山本照子
  • Organizer: 第67回日本矯正歯科学会
  • Place of Presentation: 千葉
  • Year and Date: 2008-09-16
• [Presentation] Novel roles of Ten-m/Odz3 in development of mandibular condylar cartilage (2008)
  • Author(s): Murakami T, Fukunaga T, Takeshita N, Hiratsuka K, Yamashiro T, Abiko Y, Takano-Yamamoto T
  • Organizer: 86th General Session & Exhibition of the IADR
  • Place of Presentation: Tronto Canada
  • Year and Date: 2008-07-02
• [Presentation] Novel roles of Ten-m/Odz3 in development of mandibular condylar cartilage (2008)
  • Author(s): Takashi Murakami
  • Organizer: IADR general session
  • Place of Presentation: トロント, カナダ
  • Year and Date: 2008-07-02