Clarification of pain mechanism and pain control during orthodontic treatment

Research Project

Project/Area Number	20791574
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Okayama University
Principal Investigator	YABUUCHI Toshinori Okayama University, 岡山大学病院, 医員 (00452582)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	神経ペプチド / 痛み / 共焦点顕微鏡 / 組織学的形態計測
Research Abstract	We found that the distribution of various markers in central have been changed over time during tooth movement. In trigeminal ganglion, we found that microglia and astrocytes were activated during tooth movement. In addition, activated glial cells were localized around the Fos-positive neurons. The results of studies were suggested glial cells may have been deeply involved in noxious stimulation during tooth movement.