| Project/Area Number |
20791575
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
HONJO Tadashi Okayama University, 大学院・医歯薬学総合研究科, 助教 (10379844)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 歯科矯正学 / 骨芽細胞 / 骨細胞 / アクチン結合タンパク質 / CTGF / メカニカルストレス / アクチン結合タンパク |
|---|
| Research Abstract |
we evaluated the effect of FSS on ctgf expression and investigated its mechanism in MC3T3-E1 cells. The ctgf expression was induced by FSS in a dose dependent manner up to 1.5 Pa, at which more than 5-fold induction was observed. This effect was inhibited by a Rho GTPase inhibitor, Y27632. Moreover, inhibition of actin polymerization blocked the FSS-induced activation of ctgf, whereas forced F-actin formation by jasplakinolide and cytochalasin D enhanced the ctgf expression in the same cells. Collectively, these findings indicate the role of Rho signaling pathway in bone remodeling provoked by FSS through the induction of CTGF.
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