Elucidation of an aging mechanism and an anti-aging treatment in periodontal tissue

• Project/Area Number: 20791578
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TANAKA Nobuaki Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (90397969)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 歯肉線維芽細胞 / 宿主年齢 / ヒアルロン酸 / b-FGF / 感受性

Research Abstract

We studied the effect of bFGF and different HA molecular size in GF isolated from the different host ages. The bFGF showed different action by cell density. The ability of proliferation and matrix-forming were enhanced in proliferative phase during the wound healing process, and the induction of apoptosis was also enhanced in remodeling phase. These effects were more marked in younger host.

Research Products

• [Journal Article] Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system (2010)
  • Author(s): Lin YY, Tanaka N, Ohkuma S, Iwabuchi Y, Tanne Y, Kamiya T, Kunimatsu R, Huang YC, Yoshioka M, Mitsuyoshi T, Tanimoto K, Tanaka E, Tanne K
  • Journal Title: Eur J Oral Sci (in Press)
  • Peer Reviewed
• [Journal Article] Modulation of Hyaluronan Fragmentation by Interleukin-1 Beta in Synovial Membrane Cells (2010)
  • Author(s): Tanimoto K, Yanagida T, Tanne Y, Kamiya T, Huang YC, Mitsuyoshi T, Tanaka N, Tanaka E, Tanne K
  • Journal Title: Ann Biomed Eng Jan23
  • Peer Reviewed
• [Journal Article] Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli (2009)
  • Author(s): Tanimoto K, Kitamura R, Tanne Y, Kamiya T, Kunimatsu R, Yoshioka M, Tanaka N, Tanaka E, Tanne K
  • Journal Title: J Biomed Mater Res A Jun30
  • Peer Reviewed
• [Journal Article] Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells (2009)
  • Author(s): Nakatani Y, Tanimoto K, Tanaka N, Tanne Y, Kamiya T, Kunimatsu R, Tanaka E, Tanne K
  • Journal Title: Arch Oral Biol 54(8) Pages: 757-763
  • Peer Reviewed
• [Journal Article] The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading (2009)
  • Author(s): Lin YY, Tanaka N, Ohkuma S, Kamiya T, Kunimatsu R, Huang YC, Yoshioka M, Mitsuyoshi T, Tanne Y, Tanimoto K, Tanaka E, Tanne K
  • Journal Title: Ann Biomed Eng 37(7) Pages: 1358-1367
  • Peer Reviewed
• [Journal Article] Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes (2009)
  • Author(s): Kamiya T, Tanimoto K, Tanne Y, Lin YY, Kunimatsu R, Yoshioka M, Tanaka N, Tanaka E, Tanne K
  • Journal Title: J Biomed Mater Res A. Mar11
  • Peer Reviewed
• [Journal Article] Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells (2009)
  • Author(s): Kitamura R, Tanimoto K, Tanne Y, Kamiya T, Huang YC, Tanaka N, Tanaka E, Tanne K
  • Journal Title: J Biomed Mater Res A Jan22
  • Peer Reviewed
• [Journal Article] An Adolescent Case of Skeletal Maxillary Protrusion with Osteoarthritis of the Temporomandibular Joint (2009)
  • Author(s): Michida M, Tanaka N, Tanimoto K, Tanne K
  • Journal Title: Orthod Waves (in Press)
  • Peer Reviewed
• [Journal Article] Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells. (2009)
  • Author(s): Nakatani Y
  • Journal Title: Arch Oral Biol. 54 Pages: 757-763
  • Peer Reviewed
• [Journal Article] The mandibular cartilage metabolism is altered by damaged subchondral bone from traumatic impact loading (2009)
  • Author(s): Lin YY
  • Journal Title: Ann Biomed Eng. 37 Pages: 1358-1367
  • Peer Reviewed
• [Journal Article] Expression and activity of Runx2 mediated by hyaluronan during chondrocyte differentiation (2008)
  • Author(s): Tanne Y
  • Journal Title: Arch Oral Biol. 53 Pages: 478-487
  • Peer Reviewed
• [Journal Article] Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase (2008)
  • Author(s): Tanimoto K
  • Journal Title: Arch Oral Biol. 53 Pages: 330-336
  • Peer Reviewed
• [Journal Article] The effect of mechanical loading on the metabolism of growth plate chondrocytes (2008)
  • Author(s): Ueki M
  • Journal Title: Ann Biomed Eng. 36 Pages: 793-800
  • Peer Reviewed
• [Journal Article] Modulation of hyaluronan catabolism in chondrocytes by mechanical stimuli.
  • Author(s): Tanimoto K
  • Journal Title: J Biomed Mater Res A. (in press)
  • Peer Reviewed
• [Presentation] ブタ下顎頭における軟骨下骨への侵襲が軟骨代謝に及ぼす影響 (2008)
  • Author(s): 田中伸明
  • Organizer: 第21回日本顎関節学会総会・学術大会
  • Place of Presentation: 大阪