The effect of cathepsin E on orthodontic tooth movement

Research Project

Project/Area Number	20791585
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Nagasaki University
Principal Investigator	FUJIMURA Yuji Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (70448504)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	歯の移動 / 破骨細胞 / カテプシンE / 歯科矯正学 / カテフシンE
Research Abstract	The aim of this study was to investigate the effect of cathepsin E on TNF-α induced osteoclast differentiation and orthodontic tooth movement. The numbers of TNF-α induced osteoclasts were not significantly different between WT mice and cathepsin E knockout mice. Moreover, the distance of tooth movement was also not significantly different. These results suggest that cathepsin E have no effect on TNF-α induced osteoclast. Therefore it is not prevent orthodontic tooth movement.

Report

(3 results)