| Project/Area Number |
20791623
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
KOIDE Masanori Matsumoto Dental University, 総合歯科医学研究所, 講師 (10367617)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯周病 / 歯周炎モデル / 歯槽骨吸収 / RANKL / OPG / P. g. 菌 |
|---|
| Research Abstract |
We analyzed of alveolar bones of RANKL-transgenic mice (RANKL-Tg), OPG-deficient mice (OPG-KO) and wild type littermates (WT). The alveolar bones were analyzed in wild-type (WT), RANKL-Tg and OPG-KO mice from 8-week-old to 12-week-old. To estimate alveolar bone loss, the distance from the cemento-enamel junction to the alveolar bone crest was measured by micro-CT. ABL was admitted by neither WT mice nor RANKL-Tg mice. As expected, alveolar bone loss in 12-weeks-old OPG-KO mice was about 2-fold higher than the others. These results suggest that deficiency of OPG is more effective than enhancement of RANKL production in bone resorption and alveolar bone loss.
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