Activity-dependent elimination of corticospinal synapses and NMDA receptor subtype
| Project/Area Number |
20800047
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Teikyo University |
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Principal Investigator |
OHNO Takae Teikyo University, 医学部, 助教 (60508109)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,665,000 (Direct Cost: ¥2,050,000、Indirect Cost: ¥615,000)
Fiscal Year 2009: ¥1,248,000 (Direct Cost: ¥960,000、Indirect Cost: ¥288,000)
Fiscal Year 2008: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
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| Keywords | corticospinal synapse / knockout mice / GluN2B (GluRε2 / NR2B) / GluN2A (GluRε1 / NR2A) / heterotypic co-culture / exo utero electroporation / GluN2B(GluR ε 2 / GluN2A(GluR ε 1 / optical imaging / whole cell recording / GluRε2(NR2B) / GluRε1(NR2A) |
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| Research Abstract |
By using both GluN2B (ε2) and 2A (ε1) knockout mice for the in vitro corticospinal projection system, we concluded that that GluN2B in the spinal cord is selectively involved in the CS synapse elimination. We also found that this elimination process is CaMKII-dependent by pharmacological screening
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Report
(3 results)
Research Products
(7 results)
