Study of molecular mechanism in muscle atrophy and fiber type change by using bioimaging.

• Project/Area Number: 20800079
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Tokyo Metropolitan Institute of Gerontology
• Principal Investigator: MORI Shuuichi Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 (30508677)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
• Keywords: 老化 / 筋萎縮 / 神経筋シナプス

Research Abstract

Not only atrophy of muscle fibers but also fiber type transition from fast-type to slow-type has been observed as age-related changes of skeletal muscle, however, these mechanism remain to be elucidated. In this study, generation of genetically modified mice, which could definitely distinguish between fast-type fiber and slow-type fiber by expressions of fluorescence proteins, was performed. In future, it will enable novel findings about muscular atrophy-related phenomena and biomarkers by investigating the mechanism of age-related change in fiber type using these mice.

Research Products

• [Journal Article] Hepatic insulin sensitivity assessed by integrated model of hepatic and peripheral glucose regulation. (2009)
  • Author(s): Tokuyama K, Nagasaka S, Mori S, Takahashi N, Kusaka I, Kiyonaga A, Tanaka H, Shindo M, Ishibashi S.
  • Journal Title: Diabetes Technol Ther 11 Pages: 487-92
  • Peer Reviewed
• [Journal Article] Role of the liver in glucose homeostasis in P1 3-kinase p85alpha-deficient mice. (2009)
  • Author(s): Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, Asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y.
  • Journal Title: Am J Physiol Endocrinol Metab 296
  • Peer Reviewed
• [Journal Article] Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice (2009)
  • Author(s): Aoki K
  • Journal Title: Am J Physiol Endocrinol Metab 296
  • Peer Reviewed
• [Journal Article] Hepatic insulin sensitivity assessed by integrated model of hepatic and peripheral glucose regulation (2009)
  • Author(s): Tokuyama K
  • Journal Title: Diabetes Technol Ther 11 Pages: 487-92
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Shigemoto K
  • Journal Title: Myasthenia gravis disease mechanisms and immune intervention(Linus Publication Inc.) Pages: 304-323
• [Presentation] Activation of complement is dispensable for myasthenia gravis caused by MuSK antibodies. (2009)
  • Author(s): Mori S.
  • Organizer: Society of Neuroscience
  • Place of Presentation: シカゴ(アメリカ)
  • Year and Date: 2009-10-17
• [Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies (2009)
  • Author(s): 森秀一
  • Organizer: Society of Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-10-17
• [Presentation] MuSKは神経筋シナプスの維持に重要である~研究モデル動物の確立 (2009)
  • Author(s): 森秀一
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-20
• [Presentation] MuSKは神経筋シナプスの維持に重要である～研究モデル動物の確立～ (2009)
  • Author(s): 森秀一
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-20
• [Presentation] Activation of complement is dispensable for myasthenia gravis caused by MuSK antibodies. (2009)
  • Author(s): Mori S.
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies (2009)
  • Author(s): 森秀一
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] MuSKは神経筋シナプスの維持に重要である~研究モデル動物の確立 (2009)
  • Author(s): 森秀一
  • Organizer: 日本基礎老化学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-20
• [Presentation] MuSKIは神経筋シナプスの維持に重要である～研究モデル動物の確立～ (2009)
  • Author(s): 森秀一
  • Organizer: 日本基礎老化学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-20
• [Book] Myasthenia gravis disease mechanism and immune intervention (2009)
  • Author(s): Shigemoto K, Kubo S, Mori S, Yamada S, Miyazaki T, Akiyoshi T, Maruyama S.
  • Publisher: Linus publication