| Project/Area Number |
20800079
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| Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
MORI Shuuichi Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 研究員 (30508677)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,302,000 (Direct Cost: ¥2,540,000、Indirect Cost: ¥762,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,742,000 (Direct Cost: ¥1,340,000、Indirect Cost: ¥402,000)
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| Keywords | 老化 / 筋萎縮 / 神経筋シナプス |
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| Research Abstract |
Not only atrophy of muscle fibers but also fiber type transition from fast-type to slow-type has been observed as age-related changes of skeletal muscle, however, these mechanism remain to be elucidated. In this study, generation of genetically modified mice, which could definitely distinguish between fast-type fiber and slow-type fiber by expressions of fluorescence proteins, was performed. In future, it will enable novel findings about muscular atrophy-related phenomena and biomarkers by investigating the mechanism of age-related change in fiber type using these mice.
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